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- NCIT_C76494 IAO_0000115 "An anhydrous formulation of entecavir, a synthetic analog of 2-deoxyguanosine with antiviral activity against hepatitis B virus (HBV). Entecavir is activated in vivo to a 5-triphosphate metabolite. In turn, the triphosphate form competes with the natural substrate deoxyguanosine triphosphate (dGTP) for incorporation into viral DNA. The incorporation of the activated triphosphate metabolite of entecavir inhibits the reverse transcriptase (RT) viral RNA-dependent HBV DNA polymerase and, so, the replication of viral DNA and transcription." @default.
- NCIT_C76494 NCIT_NHC0 "C76494" @default.
- NCIT_C76494 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C76494 NCIT_P108 "Entecavir Anhydrous" @default.
- NCIT_C76494 NCIT_P207 "C2699999" @default.
- NCIT_C76494 NCIT_P210 "142217-69-4" @default.
- NCIT_C76494 NCIT_P319 "NNU2O4609D" @default.
- NCIT_C76494 NCIT_P322 "FDA" @default.
- NCIT_C76494 NCIT_P350 "C12H15N5O3" @default.
- NCIT_C76494 NCIT_P366 "Entecavir_Anhydrous" @default.
- NCIT_C76494 NCIT_P368 "CHEBI:473990" @default.
- NCIT_C76494 normalizedInformationContent "100" @default.
- NCIT_C76494 referenceCount "1" @default.
- NCIT_C76494 hasExactSynonym "ENTECAVIR ANHYDROUS" @default.
- NCIT_C76494 hasExactSynonym "Entecavir Anhydrous" @default.
- NCIT_C76494 inSubset NCIT_C63923 @default.
- NCIT_C76494 type Class @default.
- NCIT_C76494 isDefinedBy ncit.owl @default.
- NCIT_C76494 label "Entecavir Anhydrous" @default.
- NCIT_C76494 subClassOf NCIT_C1589 @default.
- NCIT_C76494 subClassOf NCIT_C1908 @default.
- NCIT_C76494 subClassOf NCIT_C1909 @default.
- NCIT_C76494 subClassOf NCIT_C254 @default.
- NCIT_C76494 subClassOf NCIT_C281 @default.
- NCIT_C76494 subClassOf NCIT_C471 @default.
- NCIT_C76494 subClassOf NCIT_C76494 @default.
- NCIT_C76494 subClassOf NCIT_C97452 @default.