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- NCIT_C76665 IAO_0000115 "The hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction." @default.
- NCIT_C76665 NCIT_A32 NCIT_C1909 @default.
- NCIT_C76665 NCIT_A6 NCIT_C38142 @default.
- NCIT_C76665 NCIT_NHC0 "C76665" @default.
- NCIT_C76665 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C76665 NCIT_P107 "Alvespimycin Hydrochloride" @default.
- NCIT_C76665 NCIT_P108 "Alvespimycin Hydrochloride" @default.
- NCIT_C76665 NCIT_P207 "C2350808" @default.
- NCIT_C76665 NCIT_P210 "467214-21-7" @default.
- NCIT_C76665 NCIT_P319 "612K359T69" @default.
- NCIT_C76665 NCIT_P322 "CTRP" @default.
- NCIT_C76665 NCIT_P322 "FDA" @default.
- NCIT_C76665 NCIT_P322 "GDC" @default.
- NCIT_C76665 NCIT_P329 "378203" @default.
- NCIT_C76665 NCIT_P330 "378203" @default.
- NCIT_C76665 NCIT_P350 "C32H48N4O8.ClH" @default.
- NCIT_C76665 NCIT_P366 "Alvespimycin_Hydrochloride" @default.
- NCIT_C76665 NCIT_P375 "Alvespimycin Hydrochloride" @default.
- NCIT_C76665 NCIT_P399 "378203" @default.
- NCIT_C76665 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C76665 NCIT_R125 NCIT_C19903 @default.
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- NCIT_C76665 NCIT_R125 NCIT_C21198 @default.
- NCIT_C76665 NCIT_R125 NCIT_C28498 @default.
- NCIT_C76665 NCIT_R125 NCIT_C40673 @default.
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- NCIT_C76665 NCIT_R146 NCIT_C16672 @default.
- NCIT_C76665 NCIT_R146 NCIT_C17021 @default.
- NCIT_C76665 NCIT_R146 NCIT_C17766 @default.
- NCIT_C76665 NCIT_R146 NCIT_C20130 @default.
- NCIT_C76665 NCIT_R146 NCIT_C26548 @default.
- NCIT_C76665 normalizedInformationContent "100" @default.
- NCIT_C76665 referenceCount "1" @default.
- NCIT_C76665 hasExactSynonym "17-DMAG HCl" @default.
- NCIT_C76665 hasExactSynonym "ALVESPIMYCIN HYDROCHLORIDE" @default.
- NCIT_C76665 hasExactSynonym "Alvespimycin Hydrochloride" @default.
- NCIT_C76665 hasExactSynonym "BMS-826476" @default.
- NCIT_C76665 hasExactSynonym "Geldanamycin,17-demethoxy-17-((2-(dimethylamino)ethyl)amino)-, Monohydrochloride" @default.
- NCIT_C76665 hasExactSynonym "KOS-1022" @default.
- NCIT_C76665 inSubset NCIT_C116977 @default.
- NCIT_C76665 inSubset NCIT_C116978 @default.
- NCIT_C76665 inSubset NCIT_C128784 @default.
- NCIT_C76665 inSubset NCIT_C157711 @default.
- NCIT_C76665 inSubset NCIT_C157712 @default.
- NCIT_C76665 inSubset NCIT_C176424 @default.
- NCIT_C76665 inSubset NCIT_C177537 @default.
- NCIT_C76665 inSubset NCIT_C63923 @default.
- NCIT_C76665 type Class @default.
- NCIT_C76665 isDefinedBy ncit.owl @default.
- NCIT_C76665 label "Alvespimycin Hydrochloride" @default.
- NCIT_C76665 subClassOf NCIT_C1003 @default.
- NCIT_C76665 subClassOf NCIT_C129824 @default.
- NCIT_C76665 subClassOf NCIT_C186664 @default.
- NCIT_C76665 subClassOf NCIT_C1908 @default.
- NCIT_C76665 subClassOf NCIT_C1909 @default.
- NCIT_C76665 subClassOf NCIT_C2189 @default.
- NCIT_C76665 subClassOf NCIT_C2516 @default.
- NCIT_C76665 subClassOf NCIT_C259 @default.
- NCIT_C76665 subClassOf NCIT_C274 @default.
- NCIT_C76665 subClassOf NCIT_C74526 @default.
- NCIT_C76665 subClassOf NCIT_C76665 @default.