Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C76890> ?p ?o ?g. }
Showing items 1 to 45 of
45
with 100 items per page.
- NCIT_C76890 IAO_0000115 "An orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities. Upon administration, roflumilast and its active metabolite roflumilast N-oxide selectively and competitively bind to and inhibit PDE4, which leads to an increase of both intracellular levels of cyclic-3',5'-adenosine monophosphate (cAMP) and cAMP-mediated signaling. cAMP prevents phosphorylation of spleen tyrosine kinase (SYK) and abrogates activation of the PI3K/AKT/mTOR signaling pathway, which may result in the induction of apoptosis. PDE4, a member of the PDE superfamily that hydrolyses cAMP and 3',5'-cyclic guanosine monophosphate (cGMP) to their inactive 5' monophosphates, is upregulated in a variety of cancers and may contribute to chemoresistance; it also plays a key role in inflammation, especially in inflammatory airway diseases." @default.
- NCIT_C76890 NCIT_A32 NCIT_C1909 @default.
- NCIT_C76890 NCIT_A7 NCIT_C107433 @default.
- NCIT_C76890 NCIT_NHC0 "C76890" @default.
- NCIT_C76890 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C76890 NCIT_P107 "Roflumilast" @default.
- NCIT_C76890 NCIT_P108 "Roflumilast" @default.
- NCIT_C76890 NCIT_P207 "C0965618" @default.
- NCIT_C76890 NCIT_P210 "162401-32-3" @default.
- NCIT_C76890 NCIT_P302 "Chronic Obstructive Pulmonary Disease (COPD)" @default.
- NCIT_C76890 NCIT_P319 "0P6C6ZOP5U" @default.
- NCIT_C76890 NCIT_P322 "CTRP" @default.
- NCIT_C76890 NCIT_P322 "FDA" @default.
- NCIT_C76890 NCIT_P322 "GDC" @default.
- NCIT_C76890 NCIT_P329 "750521" @default.
- NCIT_C76890 NCIT_P330 "750521" @default.
- NCIT_C76890 NCIT_P350 "C17H14Cl2F2N2O3" @default.
- NCIT_C76890 NCIT_P366 "Roflumilast" @default.
- NCIT_C76890 NCIT_P375 "Roflumilast" @default.
- NCIT_C76890 NCIT_P399 "750521" @default.
- NCIT_C76890 normalizedInformationContent "100" @default.
- NCIT_C76890 referenceCount "1" @default.
- NCIT_C76890 hasExactSynonym "3-Cyclopropylmethoxy-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide" @default.
- NCIT_C76890 hasExactSynonym "B9302-107" @default.
- NCIT_C76890 hasExactSynonym "BY217" @default.
- NCIT_C76890 hasExactSynonym "BYK20869" @default.
- NCIT_C76890 hasExactSynonym "Daliresp" @default.
- NCIT_C76890 hasExactSynonym "ROFLUMILAST" @default.
- NCIT_C76890 hasExactSynonym "Roflumilast" @default.
- NCIT_C76890 inSubset NCIT_C116977 @default.
- NCIT_C76890 inSubset NCIT_C116978 @default.
- NCIT_C76890 inSubset NCIT_C128784 @default.
- NCIT_C76890 inSubset NCIT_C157711 @default.
- NCIT_C76890 inSubset NCIT_C157712 @default.
- NCIT_C76890 inSubset NCIT_C176424 @default.
- NCIT_C76890 inSubset NCIT_C177537 @default.
- NCIT_C76890 inSubset NCIT_C63923 @default.
- NCIT_C76890 type Class @default.
- NCIT_C76890 isDefinedBy ncit.owl @default.
- NCIT_C76890 label "Roflumilast" @default.
- NCIT_C76890 subClassOf NCIT_C1908 @default.
- NCIT_C76890 subClassOf NCIT_C1909 @default.
- NCIT_C76890 subClassOf NCIT_C471 @default.
- NCIT_C76890 subClassOf NCIT_C744 @default.
- NCIT_C76890 subClassOf NCIT_C76890 @default.