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- NCIT_C76970 IAO_0000115 "The dimaleate salt form of atiprimod, an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic activities. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and AKT, blocking the signaling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1. This results in the inhibition of cell proliferation, induction of cell cycle arrest, and apoptosis." @default.
- NCIT_C76970 NCIT_A32 NCIT_C1909 @default.
- NCIT_C76970 NCIT_A6 NCIT_C52184 @default.
- NCIT_C76970 NCIT_NHC0 "C76970" @default.
- NCIT_C76970 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C76970 NCIT_P108 "Atiprimod Dimaleate" @default.
- NCIT_C76970 NCIT_P207 "C2698191" @default.
- NCIT_C76970 NCIT_P210 "183063-72-1" @default.
- NCIT_C76970 NCIT_P319 "YNU265SSR3" @default.
- NCIT_C76970 NCIT_P322 "FDA" @default.
- NCIT_C76970 NCIT_P322 "GDC" @default.
- NCIT_C76970 NCIT_P350 "C22H44N2.2C4H4O4" @default.
- NCIT_C76970 NCIT_P366 "Atiprimod_Dimaleate" @default.
- NCIT_C76970 NCIT_P375 "Atiprimod Dimaleate" @default.
- NCIT_C76970 normalizedInformationContent "100" @default.
- NCIT_C76970 referenceCount "1" @default.
- NCIT_C76970 hasExactSynonym "ATIPRIMOD DIMALEATE" @default.
- NCIT_C76970 hasExactSynonym "Atiprimod Dimaleate" @default.
- NCIT_C76970 inSubset NCIT_C128784 @default.
- NCIT_C76970 inSubset NCIT_C157711 @default.
- NCIT_C76970 inSubset NCIT_C157712 @default.
- NCIT_C76970 inSubset NCIT_C177537 @default.
- NCIT_C76970 inSubset NCIT_C63923 @default.
- NCIT_C76970 type Class @default.
- NCIT_C76970 isDefinedBy ncit.owl @default.
- NCIT_C76970 label "Atiprimod Dimaleate" @default.
- NCIT_C76970 subClassOf NCIT_C1742 @default.
- NCIT_C76970 subClassOf NCIT_C1908 @default.
- NCIT_C76970 subClassOf NCIT_C1909 @default.
- NCIT_C76970 subClassOf NCIT_C2189 @default.
- NCIT_C76970 subClassOf NCIT_C274 @default.
- NCIT_C76970 subClassOf NCIT_C308 @default.
- NCIT_C76970 subClassOf NCIT_C76970 @default.