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- NCIT_C77387 IAO_0000115 "A synthetic triglycyllysine derivative of vasopressin with vasoconstrictive, antihemorrhagic, and antidiuretic properties. Upon intravenous administration, terlipressin, an inactive prodrug, is biotransformed to its active moiety, lysine vasopressin (LVP), a nonselective vasopressin analogue with affinity for vasopressin receptors V1 (V1a), V2 and V3 (V1b). As a V1 agonist, terlipressin increases systemic vascular resistance, particularly in the splanchnic area, resulting in a decrease of portal pressure. V1 binding also promotes platelet aggregation and glycogenolysis, while V3 binding induces adrenocorticotropic hormone (ACTH) secretion. Compared to vasopressin, terlipressin has a minimal effect on V2 receptors, which are responsible for promotion of water reabsorption in the collecting ducts of the kidney via stimulation of cyclic AMP production." @default.
- NCIT_C77387 NCIT_A5 NCIT_C99153 @default.
- NCIT_C77387 NCIT_NHC0 "C77387" @default.
- NCIT_C77387 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77387 NCIT_P108 "Terlipressin" @default.
- NCIT_C77387 NCIT_P207 "C0145185" @default.
- NCIT_C77387 NCIT_P210 "14636-12-5" @default.
- NCIT_C77387 NCIT_P319 "7Z5X49W53P" @default.
- NCIT_C77387 NCIT_P322 "FDA" @default.
- NCIT_C77387 NCIT_P329 "794786" @default.
- NCIT_C77387 NCIT_P330 "794786" @default.
- NCIT_C77387 NCIT_P350 "C52H74N16O15S2" @default.
- NCIT_C77387 NCIT_P366 "Terlipressin" @default.
- NCIT_C77387 NCIT_P399 "794786" @default.
- NCIT_C77387 normalizedInformationContent "100" @default.
- NCIT_C77387 referenceCount "1" @default.
- NCIT_C77387 hasExactSynonym "Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-Nh2 (4-9 Disulfide)" @default.
- NCIT_C77387 hasExactSynonym "N-(N-(N-Glycylglycyl)Glycyl)-8-L-Lysinevasopressin" @default.
- NCIT_C77387 hasExactSynonym "TERLIPRESSIN" @default.
- NCIT_C77387 hasExactSynonym "Terlipressin" @default.
- NCIT_C77387 inSubset NCIT_C176424 @default.
- NCIT_C77387 inSubset NCIT_C63923 @default.
- NCIT_C77387 type Class @default.
- NCIT_C77387 isDefinedBy ncit.owl @default.
- NCIT_C77387 label "Terlipressin" @default.
- NCIT_C77387 subClassOf NCIT_C147908 @default.
- NCIT_C77387 subClassOf NCIT_C1908 @default.
- NCIT_C77387 subClassOf NCIT_C1909 @default.
- NCIT_C77387 subClassOf NCIT_C548 @default.
- NCIT_C77387 subClassOf NCIT_C77387 @default.
- NCIT_C77387 subClassOf NCIT_C80212 @default.