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- NCIT_C77389 IAO_0000115 "The ethanolate form of darunavir, a human immunodeficiency virus type 1 (HIV-1) protease nonpeptidic inhibitor, with activity against HIV. Upon oral administration, darunavir selectively targets and binds to the active site of HIV-1 protease, and inhibits the dimerization and catalytic activity of HIV-1 protease. This inhibits the proteolytic cleavage of viral Gag and Gag-Pol polyproteins in HIV-infected cells. This inhibition leads to the production of immature, non-infectious viral proteins that are unable to form mature virions, and prevents HIV replication." @default.
- NCIT_C77389 NCIT_NHC0 "C77389" @default.
- NCIT_C77389 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77389 NCIT_P108 "Darunavir Ethanolate" @default.
- NCIT_C77389 NCIT_P207 "C1725651" @default.
- NCIT_C77389 NCIT_P210 "635728-49-3" @default.
- NCIT_C77389 NCIT_P319 "33O78XF0BW" @default.
- NCIT_C77389 NCIT_P322 "FDA" @default.
- NCIT_C77389 NCIT_P350 "C27H37N3O7S.C2H6O" @default.
- NCIT_C77389 NCIT_P366 "Darunavir_Ethanolate" @default.
- NCIT_C77389 normalizedInformationContent "100" @default.
- NCIT_C77389 referenceCount "1" @default.
- NCIT_C77389 hasExactSynonym "DARUNAVIR ETHANOLATE" @default.
- NCIT_C77389 hasExactSynonym "Darunavir Ethanolate" @default.
- NCIT_C77389 hasExactSynonym "Prezista" @default.
- NCIT_C77389 hasExactSynonym "TMC114" @default.
- NCIT_C77389 inSubset NCIT_C63923 @default.
- NCIT_C77389 type Class @default.
- NCIT_C77389 isDefinedBy ncit.owl @default.
- NCIT_C77389 label "Darunavir Ethanolate" @default.
- NCIT_C77389 subClassOf NCIT_C1660 @default.
- NCIT_C77389 subClassOf NCIT_C1908 @default.
- NCIT_C77389 subClassOf NCIT_C1909 @default.
- NCIT_C77389 subClassOf NCIT_C254 @default.
- NCIT_C77389 subClassOf NCIT_C281 @default.
- NCIT_C77389 subClassOf NCIT_C471 @default.
- NCIT_C77389 subClassOf NCIT_C77389 @default.
- NCIT_C77389 subClassOf NCIT_C783 @default.
- NCIT_C77389 subClassOf NCIT_C97366 @default.