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- NCIT_C77424 IAO_0000115 "The acetate salt form of histrelin, a long-acting, synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) with potential anti-tumor activity. Upon administration, histrelin binds to and activates GnRH receptors; prolonged administration results in pituitary GnRH receptor desensitization and inhibition of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion, leading to a significant decline in testosterone production in males and may inhibit androgen receptor-positive tumor progression; in females, prolonged administration results in decreased estradiol production." @default.
- NCIT_C77424 NCIT_A32 NCIT_C1909 @default.
- NCIT_C77424 NCIT_A6 NCIT_C74270 @default.
- NCIT_C77424 NCIT_NHC0 "C77424" @default.
- NCIT_C77424 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77424 NCIT_P108 "Histrelin Acetate" @default.
- NCIT_C77424 NCIT_P207 "C0724597" @default.
- NCIT_C77424 NCIT_P210 "76712-82-8" @default.
- NCIT_C77424 NCIT_P319 "QMG7HLD1ZE" @default.
- NCIT_C77424 NCIT_P322 "FDA" @default.
- NCIT_C77424 NCIT_P322 "GDC" @default.
- NCIT_C77424 NCIT_P329 "732255" @default.
- NCIT_C77424 NCIT_P330 "732255" @default.
- NCIT_C77424 NCIT_P350 "C66H86N18O12.C2H4O2.H2O" @default.
- NCIT_C77424 NCIT_P366 "Histrelin_Acetate" @default.
- NCIT_C77424 NCIT_P375 "Histrelin Acetate" @default.
- NCIT_C77424 NCIT_P399 "732255" @default.
- NCIT_C77424 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C77424 referenceCount "2" @default.
- NCIT_C77424 hasExactSynonym "HISTRELIN ACETATE" @default.
- NCIT_C77424 hasExactSynonym "Histrelin Acetate" @default.
- NCIT_C77424 hasExactSynonym "Supprelin" @default.
- NCIT_C77424 hasExactSynonym "Vantas" @default.
- NCIT_C77424 inSubset NCIT_C128784 @default.
- NCIT_C77424 inSubset NCIT_C157711 @default.
- NCIT_C77424 inSubset NCIT_C157712 @default.
- NCIT_C77424 inSubset NCIT_C176424 @default.
- NCIT_C77424 inSubset NCIT_C177537 @default.
- NCIT_C77424 inSubset NCIT_C63923 @default.
- NCIT_C77424 type Class @default.
- NCIT_C77424 isDefinedBy ncit.owl @default.
- NCIT_C77424 label "Histrelin Acetate" @default.
- NCIT_C77424 subClassOf NCIT_C147908 @default.
- NCIT_C77424 subClassOf NCIT_C1908 @default.
- NCIT_C77424 subClassOf NCIT_C1909 @default.
- NCIT_C77424 subClassOf NCIT_C1910 @default.
- NCIT_C77424 subClassOf NCIT_C548 @default.
- NCIT_C77424 subClassOf NCIT_C77424 @default.