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- NCIT_C77591 IAO_0000115 "A recombinant form of human granulocyte macrophage colony stimulating factor (GM-CSF), with potential immunostimulating activity. Upon administration as inhalation solution via nebulizer, molgramostim binds to specific cell surface receptors and promotes or restores GM-CSF signaling, thereby modulating the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production. This agent also activates neutrophils, monocytes, macrophages, and dendritic cells and promotes antigen presentation, upregulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin (IL)-2-mediated, lymphokine-activated killer cell function. In addition, the restoration of GM-CSF signaling promotes surfactant clearing by pulmonary alveolar macrophages." @default.
- NCIT_C77591 NCIT_NHC0 "C77591" @default.
- NCIT_C77591 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77591 NCIT_P108 "Molgramostim" @default.
- NCIT_C77591 NCIT_P207 "C0218633" @default.
- NCIT_C77591 NCIT_P210 "99283-10-0" @default.
- NCIT_C77591 NCIT_P319 "B321AL142J" @default.
- NCIT_C77591 NCIT_P322 "FDA" @default.
- NCIT_C77591 NCIT_P366 "Molgramostim" @default.
- NCIT_C77591 NCIT_P399 "810678" @default.
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- NCIT_C77591 NCIT_R72 NCIT_C12219 @default.
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- NCIT_C77591 normalizedInformationContent "100" @default.
- NCIT_C77591 referenceCount "1" @default.
- NCIT_C77591 hasExactSynonym "Leucomax" @default.
- NCIT_C77591 hasExactSynonym "MOLGRAMOSTIM" @default.
- NCIT_C77591 hasExactSynonym "Macrogen" @default.
- NCIT_C77591 hasExactSynonym "Molgradex" @default.
- NCIT_C77591 hasExactSynonym "Molgramostim" @default.
- NCIT_C77591 hasExactSynonym "Sch 39300" @default.
- NCIT_C77591 inSubset NCIT_C173381 @default.
- NCIT_C77591 inSubset NCIT_C173383 @default.
- NCIT_C77591 inSubset NCIT_C176424 @default.
- NCIT_C77591 inSubset NCIT_C63923 @default.
- NCIT_C77591 type Class @default.
- NCIT_C77591 isDefinedBy ncit.owl @default.
- NCIT_C77591 label "Molgramostim" @default.
- NCIT_C77591 subClassOf NCIT_C1283 @default.
- NCIT_C77591 subClassOf NCIT_C1288 @default.
- NCIT_C77591 subClassOf NCIT_C1908 @default.
- NCIT_C77591 subClassOf NCIT_C1909 @default.
- NCIT_C77591 subClassOf NCIT_C2395 @default.
- NCIT_C77591 subClassOf NCIT_C307 @default.
- NCIT_C77591 subClassOf NCIT_C308 @default.
- NCIT_C77591 subClassOf NCIT_C387 @default.
- NCIT_C77591 subClassOf NCIT_C530 @default.
- NCIT_C77591 subClassOf NCIT_C77591 @default.