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- NCIT_C77856 IAO_0000115 "A tripeptide consisting of tyrosine, serine, and leucine with potential antineoplastic activity. Although the mechanism of its antitumor activity has yet to be fully elucidated, tyroserleutide appears to inhibit the expression of ICAM-1 (CD54), a cell adhesion factor of the immunoglobulin (Ig) superfamily that plays an important role in the invasion, adhesion, and metastasis of tumor cells. In addition, this agent may influence the Ca2+/calmodulin pathway, inhibiting phosphatidylinositol 3 kinase (PI3K); PI3K is upregulated in tumor cells and is involved in cellular proliferation." @default.
- NCIT_C77856 NCIT_A32 NCIT_C1909 @default.
- NCIT_C77856 NCIT_NHC0 "C77856" @default.
- NCIT_C77856 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C77856 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77856 NCIT_P108 "Tyroserleutide" @default.
- NCIT_C77856 NCIT_P207 "C1451018" @default.
- NCIT_C77856 NCIT_P210 "138168-48-6" @default.
- NCIT_C77856 NCIT_P319 "L9TIM50J8N" @default.
- NCIT_C77856 NCIT_P322 "FDA" @default.
- NCIT_C77856 NCIT_P322 "GDC" @default.
- NCIT_C77856 NCIT_P329 "593430" @default.
- NCIT_C77856 NCIT_P330 "593430" @default.
- NCIT_C77856 NCIT_P366 "Tyroserleutide" @default.
- NCIT_C77856 NCIT_P375 "Tyroserleutide" @default.
- NCIT_C77856 NCIT_P399 "593430" @default.
- NCIT_C77856 normalizedInformationContent "100" @default.
- NCIT_C77856 referenceCount "1" @default.
- NCIT_C77856 hasExactSynonym "CMS 024" @default.
- NCIT_C77856 hasExactSynonym "TYROSERLEUTIDE" @default.
- NCIT_C77856 hasExactSynonym "Tyroserleutide" @default.
- NCIT_C77856 hasExactSynonym "YSL" @default.
- NCIT_C77856 inSubset NCIT_C128784 @default.
- NCIT_C77856 inSubset NCIT_C157711 @default.
- NCIT_C77856 inSubset NCIT_C157712 @default.
- NCIT_C77856 inSubset NCIT_C176424 @default.
- NCIT_C77856 inSubset NCIT_C177537 @default.
- NCIT_C77856 inSubset NCIT_C63923 @default.
- NCIT_C77856 type Class @default.
- NCIT_C77856 isDefinedBy ncit.owl @default.
- NCIT_C77856 label "Tyroserleutide" @default.
- NCIT_C77856 subClassOf NCIT_C1404 @default.
- NCIT_C77856 subClassOf NCIT_C163758 @default.
- NCIT_C77856 subClassOf NCIT_C1742 @default.
- NCIT_C77856 subClassOf NCIT_C1908 @default.
- NCIT_C77856 subClassOf NCIT_C1909 @default.
- NCIT_C77856 subClassOf NCIT_C2152 @default.
- NCIT_C77856 subClassOf NCIT_C274 @default.
- NCIT_C77856 subClassOf NCIT_C471 @default.
- NCIT_C77856 subClassOf NCIT_C77856 @default.