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- NCIT_C77862 IAO_0000115 "A humanized recombinant IgG4 monoclonal antibody directed against the alpha4 subunit of the integrins alpha4beta1and alpha4beta7 with immunomodulating, anti-inflammatory, and potential antineoplastic activities. Natalizumab binds to the alpha4-subunit of alpha4beta1 and alpha4beta7 integrins expressed on the surface of all leukocytes except neutrophils, inhibiting the alpha4-mediated adhesion of leukocytes to counter-receptor(s) such as vascular cell adhesion molecule-1 (VCAM-1); natalizumab-mediated disruption of VCAM-1 binding by these integrins may prevent the transmigration of leukocytes across the endothelium into inflamed parenchymal tissue. Integrins are cellular adhesion molecules (CAMs) that are upregulated in various types of cancer and some autoimmune diseases; alpha4beta1 integrin (VLA4) has been implicated in the survival of myeloma cells, possibly by mediating their adhesion to stromal cells." @default.
- NCIT_C77862 NCIT_A32 NCIT_C1909 @default.
- NCIT_C77862 NCIT_NHC0 "C77862" @default.
- NCIT_C77862 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C77862 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77862 NCIT_P107 "Natalizumab" @default.
- NCIT_C77862 NCIT_P108 "Natalizumab" @default.
- NCIT_C77862 NCIT_P207 "C1172734" @default.
- NCIT_C77862 NCIT_P210 "189261-10-7" @default.
- NCIT_C77862 NCIT_P302 "multiple sclerosis, Crohn's disease" @default.
- NCIT_C77862 NCIT_P319 "3JB47N2Q2P" @default.
- NCIT_C77862 NCIT_P322 "CTRP" @default.
- NCIT_C77862 NCIT_P322 "FDA" @default.
- NCIT_C77862 NCIT_P322 "GDC" @default.
- NCIT_C77862 NCIT_P329 "596513" @default.
- NCIT_C77862 NCIT_P330 "596513" @default.
- NCIT_C77862 NCIT_P366 "Natalizumab" @default.
- NCIT_C77862 NCIT_P375 "Natalizumab" @default.
- NCIT_C77862 NCIT_P399 "596513" @default.
- NCIT_C77862 NCIT_R124 NCIT_C17710 @default.
- NCIT_C77862 NCIT_R124 NCIT_C17828 @default.
- NCIT_C77862 NCIT_R124 NCIT_C18219 @default.
- NCIT_C77862 NCIT_R124 NCIT_C19986 @default.
- NCIT_C77862 NCIT_R124 NCIT_C40474 @default.
- NCIT_C77862 normalizedInformationContent "100" @default.
- NCIT_C77862 referenceCount "1" @default.
- NCIT_C77862 hasExactSynonym "AN100226" @default.
- NCIT_C77862 hasExactSynonym "Antegren" @default.
- NCIT_C77862 hasExactSynonym "Anti-VLA4" @default.
- NCIT_C77862 hasExactSynonym "Anti-alph4 Integrin Monoclonal Antibody AN100226" @default.
- NCIT_C77862 hasExactSynonym "NATALIZUMAB" @default.
- NCIT_C77862 hasExactSynonym "Natalizumab" @default.
- NCIT_C77862 hasExactSynonym "Tysabri" @default.
- NCIT_C77862 inSubset NCIT_C116977 @default.
- NCIT_C77862 inSubset NCIT_C116978 @default.
- NCIT_C77862 inSubset NCIT_C128784 @default.
- NCIT_C77862 inSubset NCIT_C157711 @default.
- NCIT_C77862 inSubset NCIT_C157712 @default.
- NCIT_C77862 inSubset NCIT_C176424 @default.
- NCIT_C77862 inSubset NCIT_C177537 @default.
- NCIT_C77862 inSubset NCIT_C63923 @default.
- NCIT_C77862 type Class @default.
- NCIT_C77862 isDefinedBy ncit.owl @default.
- NCIT_C77862 label "Natalizumab" @default.
- NCIT_C77862 subClassOf NCIT_C129821 @default.
- NCIT_C77862 subClassOf NCIT_C129822 @default.
- NCIT_C77862 subClassOf NCIT_C1908 @default.
- NCIT_C77862 subClassOf NCIT_C1909 @default.
- NCIT_C77862 subClassOf NCIT_C20401 @default.
- NCIT_C77862 subClassOf NCIT_C274 @default.
- NCIT_C77862 subClassOf NCIT_C307 @default.
- NCIT_C77862 subClassOf NCIT_C308 @default.
- NCIT_C77862 subClassOf NCIT_C77862 @default.