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- NCIT_C77884 IAO_0000115 "A poly-Toll-like receptor (TLR) agonist polyantigenic vaccine containing heat killed Mycobacterium indicus pranii (Mycobacterium w or Mw) with potential immunostimulating and antineoplastic activities. Upon administration, poly-TLR agonist polyantigenic vaccine activates a number of TLRs, which may result in macrophage and plasmacytoid dendritic cell (pDC) stimulation; secretion of interferon alpha; production of pro-inflammatory cytokines; upregulation of co-stimulatory molecules, enhanced T and B-cell stimulatory responses; T cell proliferation, and a Th1 immune response. TLRs are transmembrane receptors that recognize structurally conserved microbial molecules such as bacterial cell-surface lipopolysaccharides (LPS), lipoproteins, lipopeptides, lipoarabinomannan and flagellin, among others; immune responses stimulated by TLR activation may result in antineoplastic effects." @default.
- NCIT_C77884 NCIT_A32 NCIT_C1909 @default.
- NCIT_C77884 NCIT_NHC0 "C77884" @default.
- NCIT_C77884 NCIT_P106 "Organic Chemical" @default.
- NCIT_C77884 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77884 NCIT_P108 "TLR Agonist CADI-05" @default.
- NCIT_C77884 NCIT_P208 "CL387125" @default.
- NCIT_C77884 NCIT_P319 "M4PN1DW08K" @default.
- NCIT_C77884 NCIT_P322 "FDA" @default.
- NCIT_C77884 NCIT_P322 "GDC" @default.
- NCIT_C77884 NCIT_P329 "598873" @default.
- NCIT_C77884 NCIT_P330 "598873" @default.
- NCIT_C77884 NCIT_P366 "TLR_Agonist_CADI-05" @default.
- NCIT_C77884 NCIT_P375 "TLR Agonist CADI-05" @default.
- NCIT_C77884 NCIT_P399 "598873" @default.
- NCIT_C77884 normalizedInformationContent "100" @default.
- NCIT_C77884 referenceCount "1" @default.
- NCIT_C77884 hasExactSynonym "CADI-05" @default.
- NCIT_C77884 hasExactSynonym "MYCOBACTERIUM INDICUS PRANII (HEAT KILLED)" @default.
- NCIT_C77884 hasExactSynonym "Mycobacterium Indicus Pranii (Heat Killed)" @default.
- NCIT_C77884 hasExactSynonym "TLR Agonist CADI-05" @default.
- NCIT_C77884 hasExactSynonym "Toll-like Receptor Agonist CADI-05" @default.
- NCIT_C77884 inSubset NCIT_C128784 @default.
- NCIT_C77884 inSubset NCIT_C157711 @default.
- NCIT_C77884 inSubset NCIT_C157712 @default.
- NCIT_C77884 inSubset NCIT_C176424 @default.
- NCIT_C77884 inSubset NCIT_C177537 @default.
- NCIT_C77884 inSubset NCIT_C63923 @default.
- NCIT_C77884 type Class @default.
- NCIT_C77884 isDefinedBy ncit.owl @default.
- NCIT_C77884 label "TLR Agonist CADI-05" @default.
- NCIT_C77884 subClassOf NCIT_C177174 @default.
- NCIT_C77884 subClassOf NCIT_C1908 @default.
- NCIT_C77884 subClassOf NCIT_C1909 @default.
- NCIT_C77884 subClassOf NCIT_C2139 @default.
- NCIT_C77884 subClassOf NCIT_C308 @default.
- NCIT_C77884 subClassOf NCIT_C77884 @default.