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- NCIT_C77886 IAO_0000115 "A fully human, second-generation, nonfucosylated monoclonal antibody directed against the cell surface receptor CD30 with potential immunomodulating and antineoplastic activities. Anti-CD30 monoclonal antibody MDX-1401 specifically binds to the CD30 antigen, which may result in a cytotoxic T lymphocyte (CTL) response against CD30-expressing tumor cells. CD30, a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on activated lymphocytes transiently and is constitutively expressed in hematologic malignancies including Hodgkin's disease and some T-cell non-Hodgkin's lymphomas. Compared to conventional antibodies, deletion of fucose molecules on the antibody backbone, as is done in MDX-1401, may result in an increased affinity for Fc receptors and an enhanced antibody-dependent cellular cytotoxicity (ADCC)." @default.
- NCIT_C77886 NCIT_A32 NCIT_C1909 @default.
- NCIT_C77886 NCIT_A7 NCIT_C38906 @default.
- NCIT_C77886 NCIT_NHC0 "C77886" @default.
- NCIT_C77886 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C77886 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C77886 NCIT_P107 "Anti-CD30 Monoclonal Antibody MDX-1401" @default.
- NCIT_C77886 NCIT_P108 "Anti-CD30 Monoclonal Antibody MDX-1401" @default.
- NCIT_C77886 NCIT_P207 "C2703085" @default.
- NCIT_C77886 NCIT_P322 "CTRP" @default.
- NCIT_C77886 NCIT_P322 "GDC" @default.
- NCIT_C77886 NCIT_P329 "592962" @default.
- NCIT_C77886 NCIT_P330 "592962" @default.
- NCIT_C77886 NCIT_P366 "Anti-CD30_Monoclonal_Antibody_MDX-1401" @default.
- NCIT_C77886 NCIT_P375 "Anti-CD30 Monoclonal Antibody MDX-1401" @default.
- NCIT_C77886 NCIT_P399 "592962" @default.
- NCIT_C77886 NCIT_R124 NCIT_C17710 @default.
- NCIT_C77886 NCIT_R124 NCIT_C17828 @default.
- NCIT_C77886 NCIT_R124 NCIT_C18219 @default.
- NCIT_C77886 NCIT_R124 NCIT_C19986 @default.
- NCIT_C77886 NCIT_R124 NCIT_C40474 @default.
- NCIT_C77886 normalizedInformationContent "100" @default.
- NCIT_C77886 referenceCount "1" @default.
- NCIT_C77886 hasExactSynonym "Anti-CD30 Monoclonal Antibody MDX-1401" @default.
- NCIT_C77886 hasExactSynonym "MDX-1401" @default.
- NCIT_C77886 inSubset NCIT_C116977 @default.
- NCIT_C77886 inSubset NCIT_C116978 @default.
- NCIT_C77886 inSubset NCIT_C128784 @default.
- NCIT_C77886 inSubset NCIT_C157711 @default.
- NCIT_C77886 inSubset NCIT_C157712 @default.
- NCIT_C77886 inSubset NCIT_C176424 @default.
- NCIT_C77886 inSubset NCIT_C177537 @default.
- NCIT_C77886 type Class @default.
- NCIT_C77886 isDefinedBy ncit.owl @default.
- NCIT_C77886 label "Anti-CD30 Monoclonal Antibody MDX-1401" @default.
- NCIT_C77886 subClassOf NCIT_C129821 @default.
- NCIT_C77886 subClassOf NCIT_C129822 @default.
- NCIT_C77886 subClassOf NCIT_C163758 @default.
- NCIT_C77886 subClassOf NCIT_C164002 @default.
- NCIT_C77886 subClassOf NCIT_C164005 @default.
- NCIT_C77886 subClassOf NCIT_C1908 @default.
- NCIT_C77886 subClassOf NCIT_C1909 @default.
- NCIT_C77886 subClassOf NCIT_C20401 @default.
- NCIT_C77886 subClassOf NCIT_C274 @default.
- NCIT_C77886 subClassOf NCIT_C307 @default.
- NCIT_C77886 subClassOf NCIT_C308 @default.
- NCIT_C77886 subClassOf NCIT_C77886 @default.