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- NCIT_C77899 IAO_0000115 "An orally bioavailable retinoid acid receptor alpha (RARalpha) agonist and vitamin A derivative, with potential antineoplastic activity. Upon administration, RARalpha agonist IRX5183 binds to and activates RARalpha, which promotes RARalpha-mediated signaling. This results in the transcription of RARalpha-responsive genes, which are responsible for cellular differentiation and proliferation. This results in the induction of cellular differentiation and apoptosis, and leads to the inhibition of cellular proliferation and tumorigenesis. RARalpha is a nuclear receptor and a member of the steroid receptor superfamily; reduced RARalpha signaling is correlated with cancer development in a variety of cancer cell types." @default.
- NCIT_C77899 NCIT_A32 NCIT_C1909 @default.
- NCIT_C77899 NCIT_A7 NCIT_C17533 @default.
- NCIT_C77899 NCIT_NHC0 "C77899" @default.
- NCIT_C77899 NCIT_P106 "Organic Chemical" @default.
- NCIT_C77899 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77899 NCIT_P107 "RARalpha Agonist IRX5183" @default.
- NCIT_C77899 NCIT_P108 "RARalpha Agonist IRX5183" @default.
- NCIT_C77899 NCIT_P207 "C1527761" @default.
- NCIT_C77899 NCIT_P210 "367273-07-2" @default.
- NCIT_C77899 NCIT_P319 "RC87L028HU" @default.
- NCIT_C77899 NCIT_P322 "CTRP" @default.
- NCIT_C77899 NCIT_P322 "FDA" @default.
- NCIT_C77899 NCIT_P322 "GDC" @default.
- NCIT_C77899 NCIT_P329 "596530" @default.
- NCIT_C77899 NCIT_P330 "596530" @default.
- NCIT_C77899 NCIT_P366 "Retinoid_Analogue_NRX_195183" @default.
- NCIT_C77899 NCIT_P375 "RARalpha Agonist IRX5183" @default.
- NCIT_C77899 NCIT_P399 "596530" @default.
- NCIT_C77899 normalizedInformationContent "100" @default.
- NCIT_C77899 referenceCount "1" @default.
- NCIT_C77899 hasExactSynonym "AGN 195183" @default.
- NCIT_C77899 hasExactSynonym "AGN-195183" @default.
- NCIT_C77899 hasExactSynonym "IRX 5183" @default.
- NCIT_C77899 hasExactSynonym "IRX-5183" @default.
- NCIT_C77899 hasExactSynonym "IRX5183" @default.
- NCIT_C77899 hasExactSynonym "NRX 195183" @default.
- NCIT_C77899 hasExactSynonym "NRX195183" @default.
- NCIT_C77899 hasExactSynonym "RARa Agonist IRX5183" @default.
- NCIT_C77899 hasExactSynonym "RARalpha Agonist IRX5183" @default.
- NCIT_C77899 hasExactSynonym "VTP 195183" @default.
- NCIT_C77899 hasExactSynonym "VTP-195183" @default.
- NCIT_C77899 inSubset NCIT_C116977 @default.
- NCIT_C77899 inSubset NCIT_C116978 @default.
- NCIT_C77899 inSubset NCIT_C128784 @default.
- NCIT_C77899 inSubset NCIT_C157711 @default.
- NCIT_C77899 inSubset NCIT_C157712 @default.
- NCIT_C77899 inSubset NCIT_C176424 @default.
- NCIT_C77899 inSubset NCIT_C177537 @default.
- NCIT_C77899 inSubset NCIT_C63923 @default.
- NCIT_C77899 type Class @default.
- NCIT_C77899 isDefinedBy ncit.owl @default.
- NCIT_C77899 label "RARalpha Agonist IRX5183" @default.
- NCIT_C77899 subClassOf NCIT_C129820 @default.
- NCIT_C77899 subClassOf NCIT_C163758 @default.
- NCIT_C77899 subClassOf NCIT_C1908 @default.
- NCIT_C77899 subClassOf NCIT_C1909 @default.
- NCIT_C77899 subClassOf NCIT_C1934 @default.
- NCIT_C77899 subClassOf NCIT_C2122 @default.
- NCIT_C77899 subClassOf NCIT_C274 @default.
- NCIT_C77899 subClassOf NCIT_C308 @default.
- NCIT_C77899 subClassOf NCIT_C77899 @default.
- NCIT_C77899 subClassOf NCIT_C804 @default.