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- NCIT_C77906 IAO_0000115 "A small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. Pevonedistat binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival. NAE activates Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8), an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP). Functioning in diverse regulatory activities, proteins conjugated to UBLs like Nedd8 typically are not targeted for proteasomal degradation." @default.
- NCIT_C77906 NCIT_A32 NCIT_C1909 @default.
- NCIT_C77906 NCIT_A7 NCIT_C95815 @default.
- NCIT_C77906 NCIT_NHC0 "C77906" @default.
- NCIT_C77906 NCIT_P106 "Organic Chemical" @default.
- NCIT_C77906 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77906 NCIT_P107 "Pevonedistat" @default.
- NCIT_C77906 NCIT_P108 "Pevonedistat" @default.
- NCIT_C77906 NCIT_P207 "C2703093" @default.
- NCIT_C77906 NCIT_P210 "905579-51-3" @default.
- NCIT_C77906 NCIT_P319 "S3AZD8D215" @default.
- NCIT_C77906 NCIT_P322 "CTRP" @default.
- NCIT_C77906 NCIT_P322 "FDA" @default.
- NCIT_C77906 NCIT_P322 "GDC" @default.
- NCIT_C77906 NCIT_P329 "596795" @default.
- NCIT_C77906 NCIT_P330 "596795" @default.
- NCIT_C77906 NCIT_P366 "NAE_Inhibitor_MLN4924" @default.
- NCIT_C77906 NCIT_P375 "Pevonedistat" @default.
- NCIT_C77906 NCIT_P399 "596795" @default.
- NCIT_C77906 normalizedInformationContent "100" @default.
- NCIT_C77906 referenceCount "1" @default.
- NCIT_C77906 hasExactSynonym "((1S,2S,4R)-4-(4-((1S)-2,3-Dihydro-1H-inden-1-ylamino)-7H-pyrrolo(2,3-d)pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl Sulphamate" @default.
- NCIT_C77906 hasExactSynonym "MLN4924" @default.
- NCIT_C77906 hasExactSynonym "Nedd8-Activating Enzyme Inhibitor MLN4924" @default.
- NCIT_C77906 hasExactSynonym "PEVONEDISTAT" @default.
- NCIT_C77906 hasExactSynonym "Pevonedistat" @default.
- NCIT_C77906 inSubset NCIT_C116977 @default.
- NCIT_C77906 inSubset NCIT_C116978 @default.
- NCIT_C77906 inSubset NCIT_C128784 @default.
- NCIT_C77906 inSubset NCIT_C157711 @default.
- NCIT_C77906 inSubset NCIT_C157712 @default.
- NCIT_C77906 inSubset NCIT_C176424 @default.
- NCIT_C77906 inSubset NCIT_C177537 @default.
- NCIT_C77906 inSubset NCIT_C63923 @default.
- NCIT_C77906 type Class @default.
- NCIT_C77906 isDefinedBy ncit.owl @default.
- NCIT_C77906 label "Pevonedistat" @default.
- NCIT_C77906 subClassOf NCIT_C129824 @default.
- NCIT_C77906 subClassOf NCIT_C129825 @default.
- NCIT_C77906 subClassOf NCIT_C1908 @default.
- NCIT_C77906 subClassOf NCIT_C1909 @default.
- NCIT_C77906 subClassOf NCIT_C2189 @default.
- NCIT_C77906 subClassOf NCIT_C274 @default.
- NCIT_C77906 subClassOf NCIT_C471 @default.
- NCIT_C77906 subClassOf NCIT_C77906 @default.