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- NCIT_C77907 IAO_0000115 "A cancer vaccine in which autologous dendritic cells are transfected with patient-specific renal cell carcinoma (RCC) RNA and a synthetic, truncated human CD40 ligand (CD40L) RNA with potential immunostimulatory and antineoplastic activities. Individual RCC-specific RNA, encoding a unique repertoire of tumor-associated antigens (TAAs) (including telomerase reverse transcriptase, G250, and oncofetal antigen) is electroporated into autologous dendritic cells (DCs), transfected with synthetic RNA that encodes a truncated version of the T-cell protein CD40L; the transfected autologous DCs express and process both patient-specific RCC TAAs and the truncated CD40L protein. When reintroduced back to the patient, rocapuldencel-T may elicit a highly specific cytotoxic T-cell (CTL) response against RCC cells expressing the patient-specific RCC TAA repertoire. The signal cascade initiated by stimulation of the truncated, ectopically expressed co-stimulatory molecule CD40L results in the secretion of the inflammatory cytokine IL-12 downstream." @default.
- NCIT_C77907 NCIT_A32 NCIT_C1909 @default.
- NCIT_C77907 NCIT_NHC0 "C77907" @default.
- NCIT_C77907 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C77907 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C77907 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77907 NCIT_P107 "Rocapuldencel-T" @default.
- NCIT_C77907 NCIT_P108 "Rocapuldencel-T" @default.
- NCIT_C77907 NCIT_P208 "CL387046" @default.
- NCIT_C77907 NCIT_P319 "8I9S6401XZ" @default.
- NCIT_C77907 NCIT_P322 "CTRP" @default.
- NCIT_C77907 NCIT_P322 "FDA" @default.
- NCIT_C77907 NCIT_P322 "GDC" @default.
- NCIT_C77907 NCIT_P329 "599024" @default.
- NCIT_C77907 NCIT_P330 "599024" @default.
- NCIT_C77907 NCIT_P366 "Renal_Tumor_RNA_CD40L-Transfected_Dendritic_Cell_Vaccine" @default.
- NCIT_C77907 NCIT_P375 "Rocapuldencel-T" @default.
- NCIT_C77907 NCIT_P399 "599024" @default.
- NCIT_C77907 normalizedInformationContent "100" @default.
- NCIT_C77907 referenceCount "1" @default.
- NCIT_C77907 hasExactSynonym "AGS-003" @default.
- NCIT_C77907 hasExactSynonym "CMN-001" @default.
- NCIT_C77907 hasExactSynonym "ROCAPULDENCEL-T" @default.
- NCIT_C77907 hasExactSynonym "Rocapuldencel-T" @default.
- NCIT_C77907 inSubset NCIT_C116977 @default.
- NCIT_C77907 inSubset NCIT_C116978 @default.
- NCIT_C77907 inSubset NCIT_C128784 @default.
- NCIT_C77907 inSubset NCIT_C157711 @default.
- NCIT_C77907 inSubset NCIT_C157712 @default.
- NCIT_C77907 inSubset NCIT_C176424 @default.
- NCIT_C77907 inSubset NCIT_C177537 @default.
- NCIT_C77907 inSubset NCIT_C63923 @default.
- NCIT_C77907 type Class @default.
- NCIT_C77907 isDefinedBy ncit.owl @default.
- NCIT_C77907 label "Rocapuldencel-T" @default.
- NCIT_C77907 subClassOf NCIT_C129820 @default.
- NCIT_C77907 subClassOf NCIT_C1663 @default.
- NCIT_C77907 subClassOf NCIT_C1908 @default.
- NCIT_C77907 subClassOf NCIT_C1909 @default.
- NCIT_C77907 subClassOf NCIT_C274 @default.
- NCIT_C77907 subClassOf NCIT_C28308 @default.
- NCIT_C77907 subClassOf NCIT_C28310 @default.
- NCIT_C77907 subClassOf NCIT_C307 @default.
- NCIT_C77907 subClassOf NCIT_C308 @default.
- NCIT_C77907 subClassOf NCIT_C77907 @default.
- NCIT_C77907 subClassOf NCIT_C923 @default.