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- NCIT_C77908 IAO_0000115 "An orally bioavailable inhibitor of mitogen-activated protein kinase kinase (MAP2K; MAPK/ERK kinase; MEK) 1 and 2, with potential antineoplastic activity. Upon oral administration, trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor-mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity serine/threonine and tyrosine kinases often upregulated in various cancer cell types, play a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth." @default.
- NCIT_C77908 NCIT_A32 NCIT_C1909 @default.
- NCIT_C77908 NCIT_A7 NCIT_C105947 @default.
- NCIT_C77908 NCIT_NHC0 "C77908" @default.
- NCIT_C77908 NCIT_P106 "Organic Chemical" @default.
- NCIT_C77908 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77908 NCIT_P107 "Trametinib" @default.
- NCIT_C77908 NCIT_P108 "Trametinib" @default.
- NCIT_C77908 NCIT_P207 "C2697961" @default.
- NCIT_C77908 NCIT_P210 "871700-17-3" @default.
- NCIT_C77908 NCIT_P302 "metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation; unresectable or metastatic melanoma with BRAF V600E or V600K mutations" @default.
- NCIT_C77908 NCIT_P319 "33E86K87QN" @default.
- NCIT_C77908 NCIT_P322 "CTRP" @default.
- NCIT_C77908 NCIT_P322 "FDA" @default.
- NCIT_C77908 NCIT_P322 "GDC" @default.
- NCIT_C77908 NCIT_P350 "C26H23FIN5O4" @default.
- NCIT_C77908 NCIT_P366 "MEK_Inhibitor_GSK1120212" @default.
- NCIT_C77908 NCIT_P375 "Trametinib" @default.
- NCIT_C77908 normalizedInformationContent "90.826665450122817" @default.
- NCIT_C77908 referenceCount "4" @default.
- NCIT_C77908 hasExactSynonym "GSK 1120212" @default.
- NCIT_C77908 hasExactSynonym "GSK-1120212" @default.
- NCIT_C77908 hasExactSynonym "GSK1120212" @default.
- NCIT_C77908 hasExactSynonym "JTP-74057" @default.
- NCIT_C77908 hasExactSynonym "MEK Inhibitor GSK1120212" @default.
- NCIT_C77908 hasExactSynonym "N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide" @default.
- NCIT_C77908 hasExactSynonym "TRAMETINIB" @default.
- NCIT_C77908 hasExactSynonym "Trametinib" @default.
- NCIT_C77908 inSubset NCIT_C116977 @default.
- NCIT_C77908 inSubset NCIT_C116978 @default.
- NCIT_C77908 inSubset NCIT_C128784 @default.
- NCIT_C77908 inSubset NCIT_C157711 @default.
- NCIT_C77908 inSubset NCIT_C157712 @default.
- NCIT_C77908 inSubset NCIT_C177537 @default.
- NCIT_C77908 inSubset NCIT_C63923 @default.
- NCIT_C77908 type Class @default.
- NCIT_C77908 isDefinedBy ncit.owl @default.
- NCIT_C77908 label "Trametinib" @default.
- NCIT_C77908 subClassOf NCIT_C129824 @default.
- NCIT_C77908 subClassOf NCIT_C129825 @default.
- NCIT_C77908 subClassOf NCIT_C1404 @default.
- NCIT_C77908 subClassOf NCIT_C163758 @default.
- NCIT_C77908 subClassOf NCIT_C1908 @default.
- NCIT_C77908 subClassOf NCIT_C1909 @default.
- NCIT_C77908 subClassOf NCIT_C2189 @default.
- NCIT_C77908 subClassOf NCIT_C274 @default.
- NCIT_C77908 subClassOf NCIT_C471 @default.
- NCIT_C77908 subClassOf NCIT_C69145 @default.
- NCIT_C77908 subClassOf NCIT_C77908 @default.