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- NCIT_C77910 IAO_0000115 "A cancer vaccine consisting of a recombinant adenoviral vector encoding the tumor-associated antigen (TAA) human MUC-1 (hMUC-1) linked to the extracellular domain (ecd) of the co-stimulatory molecule CD40 ligand (CD40L) and an adenovirus signal sequence that encodes a secretory signal peptide (Ad-sig) with potential immunostimulating and antineoplastic activities. Due to the presence of the secretory signal peptide expressed by Ad-sig in the vaccine construct, transfected cells may secrete a fusion protein composed of hMUC-1 and the CD40L ecd. The CD40L moiety part of the fusion protein binds to CD40 receptors on dendritic cells (DCs). Subsequently, DCs may be activated and migrate, T-cells may expand, and a cytotoxic T lymphocyte (CTL) response against tumor cells that overexpress hMUC-1 may follow. MUC-1 is a hypoglycosylated TAA overexpressed by epithelial cancer cells." @default.
- NCIT_C77910 NCIT_NHC0 "C77910" @default.
- NCIT_C77910 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C77910 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C77910 NCIT_P108 "Ad-sig-hMUC-1/ecdCD40L Vaccine" @default.
- NCIT_C77910 NCIT_P208 "CL386701" @default.
- NCIT_C77910 NCIT_P329 "599246" @default.
- NCIT_C77910 NCIT_P330 "599246" @default.
- NCIT_C77910 NCIT_P366 "Ad-sig-hMUC-1_ecdCD40L_Vaccine" @default.
- NCIT_C77910 NCIT_P399 "599246" @default.
- NCIT_C77910 normalizedInformationContent "100" @default.
- NCIT_C77910 referenceCount "1" @default.
- NCIT_C77910 hasExactSynonym "Ad-sig-hMUC-1/ecdCD40L Adenoviral Vector Vaccine" @default.
- NCIT_C77910 hasExactSynonym "Ad-sig-hMUC-1/ecdCD40L Vaccine" @default.
- NCIT_C77910 inSubset NCIT_C128784 @default.
- NCIT_C77910 inSubset NCIT_C176424 @default.
- NCIT_C77910 type Class @default.
- NCIT_C77910 isDefinedBy ncit.owl @default.
- NCIT_C77910 label "Ad-sig-hMUC-1/ecdCD40L Vaccine" @default.
- NCIT_C77910 subClassOf NCIT_C129820 @default.
- NCIT_C77910 subClassOf NCIT_C1572 @default.
- NCIT_C77910 subClassOf NCIT_C1908 @default.
- NCIT_C77910 subClassOf NCIT_C1909 @default.
- NCIT_C77910 subClassOf NCIT_C274 @default.
- NCIT_C77910 subClassOf NCIT_C307 @default.
- NCIT_C77910 subClassOf NCIT_C308 @default.
- NCIT_C77910 subClassOf NCIT_C49146 @default.
- NCIT_C77910 subClassOf NCIT_C77910 @default.
- NCIT_C77910 subClassOf NCIT_C923 @default.
- NCIT_C77910 subClassOf NCIT_C96404 @default.