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- NCIT_C77911 IAO_0000115 "A radioimmunoconjugate comprised of a recombinant scFv dimer diabody of a monoclonal antibody against human carcinoembryonic antigen (CEA) labeled with iodine I 123 (I-123) with potential radioimmunolocalization applications. The antibody moiety of iodine I 123 anti-CEA recombinant diabody T84.66 binds to cells expressing CEA, selectively delivering I-123 upon cellular internalization and allowing the scintigraphic imaging of CEA-expressing tumor cells. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers. Compared to whole monoclonal antibodies, diabody fragments offer the advantages of rapid tumor targeting, rapid blood clearance, more uniform tumor distribution, and a lower potential for eliciting an immune response." @default.
- NCIT_C77911 NCIT_A7 NCIT_C16384 @default.
- NCIT_C77911 NCIT_NHC0 "C77911" @default.
- NCIT_C77911 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C77911 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C77911 NCIT_P107 "Iodine I 123 Anti-CEA Recombinant Diabody T84.66" @default.
- NCIT_C77911 NCIT_P108 "Iodine I 123 Anti-CEA Recombinant Diabody T84.66" @default.
- NCIT_C77911 NCIT_P208 "CL383557" @default.
- NCIT_C77911 NCIT_P322 "CTRP" @default.
- NCIT_C77911 NCIT_P329 "592881" @default.
- NCIT_C77911 NCIT_P330 "592881" @default.
- NCIT_C77911 NCIT_P366 "Iodine_I_123_Anti-CEA_Recombinant_Diabody_T84_66" @default.
- NCIT_C77911 NCIT_P399 "592881" @default.
- NCIT_C77911 normalizedInformationContent "100" @default.
- NCIT_C77911 referenceCount "1" @default.
- NCIT_C77911 hasExactSynonym "Iodine I 123 Anti-CEA Recombinant Diabody T84.66" @default.
- NCIT_C77911 inSubset NCIT_C116977 @default.
- NCIT_C77911 inSubset NCIT_C116978 @default.
- NCIT_C77911 inSubset NCIT_C176424 @default.
- NCIT_C77911 type Class @default.
- NCIT_C77911 isDefinedBy ncit.owl @default.
- NCIT_C77911 label "Iodine I 123 Anti-CEA Recombinant Diabody T84.66" @default.
- NCIT_C77911 subClassOf NCIT_C1446 @default.
- NCIT_C77911 subClassOf NCIT_C1511 @default.
- NCIT_C77911 subClassOf NCIT_C1512 @default.
- NCIT_C77911 subClassOf NCIT_C1908 @default.
- NCIT_C77911 subClassOf NCIT_C1909 @default.
- NCIT_C77911 subClassOf NCIT_C2124 @default.
- NCIT_C77911 subClassOf NCIT_C307 @default.
- NCIT_C77911 subClassOf NCIT_C308 @default.
- NCIT_C77911 subClassOf NCIT_C77911 @default.