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- NCIT_C77912 IAO_0000115 "An orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation." @default.
- NCIT_C77912 NCIT_A32 NCIT_C1909 @default.
- NCIT_C77912 NCIT_A7 NCIT_C16682 @default.
- NCIT_C77912 NCIT_NHC0 "C77912" @default.
- NCIT_C77912 NCIT_P106 "Organic Chemical" @default.
- NCIT_C77912 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77912 NCIT_P107 "Quisinostat" @default.
- NCIT_C77912 NCIT_P108 "Quisinostat" @default.
- NCIT_C77912 NCIT_P207 "C2703097" @default.
- NCIT_C77912 NCIT_P210 "875320-29-9" @default.
- NCIT_C77912 NCIT_P319 "9BJ85K1J8S" @default.
- NCIT_C77912 NCIT_P322 "CTRP" @default.
- NCIT_C77912 NCIT_P322 "FDA" @default.
- NCIT_C77912 NCIT_P322 "GDC" @default.
- NCIT_C77912 NCIT_P329 "596704" @default.
- NCIT_C77912 NCIT_P330 "596704" @default.
- NCIT_C77912 NCIT_P350 "C21H26N6O2" @default.
- NCIT_C77912 NCIT_P366 "HDAC_Inhibitor_JNJ-26481585" @default.
- NCIT_C77912 NCIT_P375 "Quisinostat" @default.
- NCIT_C77912 NCIT_P399 "596704" @default.
- NCIT_C77912 normalizedInformationContent "100" @default.
- NCIT_C77912 referenceCount "1" @default.
- NCIT_C77912 hasExactSynonym "HDAC Inhibitor JNJ-26481585" @default.
- NCIT_C77912 hasExactSynonym "JNJ-26481585" @default.
- NCIT_C77912 hasExactSynonym "QUISINOSTAT" @default.
- NCIT_C77912 hasExactSynonym "Quisinostat" @default.
- NCIT_C77912 inSubset NCIT_C116977 @default.
- NCIT_C77912 inSubset NCIT_C116978 @default.
- NCIT_C77912 inSubset NCIT_C128784 @default.
- NCIT_C77912 inSubset NCIT_C157711 @default.
- NCIT_C77912 inSubset NCIT_C157712 @default.
- NCIT_C77912 inSubset NCIT_C176424 @default.
- NCIT_C77912 inSubset NCIT_C177537 @default.
- NCIT_C77912 inSubset NCIT_C63923 @default.
- NCIT_C77912 type Class @default.
- NCIT_C77912 isDefinedBy ncit.owl @default.
- NCIT_C77912 label "Quisinostat" @default.
- NCIT_C77912 subClassOf B53a1e354ced96cc2ccf1d646fe960195 @default.
- NCIT_C77912 subClassOf B8ffc9af87e6e6ae2b4e17c47cd4d5115 @default.
- NCIT_C77912 subClassOf NCIT_C163758 @default.
- NCIT_C77912 subClassOf NCIT_C1908 @default.
- NCIT_C77912 subClassOf NCIT_C1909 @default.
- NCIT_C77912 subClassOf NCIT_C1946 @default.
- NCIT_C77912 subClassOf NCIT_C274 @default.
- NCIT_C77912 subClassOf NCIT_C471 @default.
- NCIT_C77912 subClassOf NCIT_C77912 @default.