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- NCIT_C77948 IAO_0000115 "A small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Upon intramuscular administration, cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells. In addition, this agent is able to increase the production and release of interferon (IFN) alpha and beta. PR is often downregulated in endometrial cancer and makes it resistant to progestin-mediated hormone therapy." @default.
- NCIT_C77948 NCIT_A5 NCIT_C114298 @default.
- NCIT_C77948 NCIT_NHC0 "C77948" @default.
- NCIT_C77948 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C77948 NCIT_P108 "Cridanimod" @default.
- NCIT_C77948 NCIT_P207 "C0044659" @default.
- NCIT_C77948 NCIT_P210 "38609-97-1" @default.
- NCIT_C77948 NCIT_P319 "X91E9EME19" @default.
- NCIT_C77948 NCIT_P322 "FDA" @default.
- NCIT_C77948 NCIT_P350 "C15H11NO3" @default.
- NCIT_C77948 NCIT_P366 "Cridanimod" @default.
- NCIT_C77948 normalizedInformationContent "100" @default.
- NCIT_C77948 referenceCount "1" @default.
- NCIT_C77948 hasExactSynonym "CRIDANIMOD" @default.
- NCIT_C77948 hasExactSynonym "Cridanimod" @default.
- NCIT_C77948 inSubset NCIT_C63923 @default.
- NCIT_C77948 type Class @default.
- NCIT_C77948 isDefinedBy ncit.owl @default.
- NCIT_C77948 label "Cridanimod" @default.
- NCIT_C77948 subClassOf NCIT_C1908 @default.
- NCIT_C77948 subClassOf NCIT_C1909 @default.
- NCIT_C77948 subClassOf NCIT_C2140 @default.
- NCIT_C77948 subClassOf NCIT_C77948 @default.