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- NCIT_C78186 IAO_0000115 "The phosphate salt form of rucaparib, an orally bioavailable tricyclic indole and inhibitor of poly(ADP-ribose) polymerases (PARPs) 1 (PARP1), 2 (PARP2) and 3 (PARP3), with potential chemo/radiosensitizing and antineoplastic activities. Upon administration, rucaparib selectively binds to PARP1, 2 and 3 and inhibits PARP-mediated DNA repair. This enhances the accumulation of DNA strand breaks, promotes genomic instability and induces cell cycle arrest and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARPs are enzymes activated by single-strand DNA breaks that catalyze the post-translational ADP-ribosylation of nuclear proteins, which induces signaling and the recruitment of other proteins to repair damaged DNA. The PARP-mediated repair pathway plays a key role in DNA repair and is dysregulated in a variety of cancer cell types." @default.
- NCIT_C78186 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78186 NCIT_A7 NCIT_C104720 @default.
- NCIT_C78186 NCIT_A7 NCIT_C147980 @default.
- NCIT_C78186 NCIT_A7 NCIT_C48215 @default.
- NCIT_C78186 NCIT_NHC0 "C78186" @default.
- NCIT_C78186 NCIT_P106 "Organic Chemical" @default.
- NCIT_C78186 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78186 NCIT_P107 "Rucaparib Phosphate" @default.
- NCIT_C78186 NCIT_P108 "Rucaparib Phosphate" @default.
- NCIT_C78186 NCIT_P207 "C2603422" @default.
- NCIT_C78186 NCIT_P210 "459868-92-9" @default.
- NCIT_C78186 NCIT_P319 "H3M9955244" @default.
- NCIT_C78186 NCIT_P322 "CTRP" @default.
- NCIT_C78186 NCIT_P322 "FDA" @default.
- NCIT_C78186 NCIT_P322 "GDC" @default.
- NCIT_C78186 NCIT_P325 "A substance being studied in the treatment of breast cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. AG014699 may cause cancer cells to die. It is a type of poly(ADP-ribose) polymerase inhibitor." @default.
- NCIT_C78186 NCIT_P329 "594405" @default.
- NCIT_C78186 NCIT_P330 "594405" @default.
- NCIT_C78186 NCIT_P350 "C19H18FN3O.H3O4P" @default.
- NCIT_C78186 NCIT_P366 "PARP-1_Inhibitor_AG014699" @default.
- NCIT_C78186 NCIT_P375 "Rucaparib Phosphate" @default.
- NCIT_C78186 NCIT_P399 "594405" @default.
- NCIT_C78186 NCIT_R146 NCIT_C104101 @default.
- NCIT_C78186 NCIT_R146 NCIT_C16554 @default.
- NCIT_C78186 NCIT_R146 NCIT_C17021 @default.
- NCIT_C78186 NCIT_R146 NCIT_C17210 @default.
- NCIT_C78186 NCIT_R146 NCIT_C17434 @default.
- NCIT_C78186 NCIT_R146 NCIT_C20027 @default.
- NCIT_C78186 NCIT_R146 NCIT_C21170 @default.
- NCIT_C78186 NCIT_R146 NCIT_C26548 @default.
- NCIT_C78186 NCIT_R146 NCIT_C48215 @default.
- NCIT_C78186 normalizedInformationContent "100" @default.
- NCIT_C78186 referenceCount "1" @default.
- NCIT_C78186 hasExactSynonym "AG-014699" @default.
- NCIT_C78186 hasExactSynonym "AG014699" @default.
- NCIT_C78186 hasExactSynonym "PARP-1 inhibitor AG014699" @default.
- NCIT_C78186 hasExactSynonym "PARP1 Inhibitor PF-01367338" @default.
- NCIT_C78186 hasExactSynonym "PF-01367338" @default.
- NCIT_C78186 hasExactSynonym "RUCAPARIB PHOSPHATE" @default.
- NCIT_C78186 hasExactSynonym "Rucaparib Phosphate" @default.
- NCIT_C78186 inSubset NCIT_C116977 @default.
- NCIT_C78186 inSubset NCIT_C116978 @default.
- NCIT_C78186 inSubset NCIT_C128784 @default.
- NCIT_C78186 inSubset NCIT_C157711 @default.
- NCIT_C78186 inSubset NCIT_C157712 @default.
- NCIT_C78186 inSubset NCIT_C176424 @default.
- NCIT_C78186 inSubset NCIT_C177537 @default.
- NCIT_C78186 inSubset NCIT_C63923 @default.
- NCIT_C78186 type Class @default.
- NCIT_C78186 isDefinedBy ncit.owl @default.
- NCIT_C78186 label "Rucaparib Phosphate" @default.
- NCIT_C78186 subClassOf NCIT_C163758 @default.
- NCIT_C78186 subClassOf NCIT_C1908 @default.
- NCIT_C78186 subClassOf NCIT_C1909 @default.
- NCIT_C78186 subClassOf NCIT_C274 @default.
- NCIT_C78186 subClassOf NCIT_C471 @default.
- NCIT_C78186 subClassOf NCIT_C62554 @default.
- NCIT_C78186 subClassOf NCIT_C78186 @default.