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- NCIT_C78194 IAO_0000115 "The hydrochloride salt form of an orally bioavailable multitargeted receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Ponatinib inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. This agent also inhibits other tyrosine kinases including those associated with vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs); in addition, it inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3). RTK inhibition by ponatinib may result in the inhibition of cellular proliferation and angiogenesis and may induce cell death. Bcr-Abl is a fusion tyrosine kinase encoded by the Philadelphia chromosome." @default.
- NCIT_C78194 NCIT_A32 NCIT_C1909 @default.
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- NCIT_C78194 NCIT_A7 NCIT_C17293 @default.
- NCIT_C78194 NCIT_A7 NCIT_C17297 @default.
- NCIT_C78194 NCIT_A7 NCIT_C18488 @default.
- NCIT_C78194 NCIT_A7 NCIT_C26202 @default.
- NCIT_C78194 NCIT_NHC0 "C78194" @default.
- NCIT_C78194 NCIT_P106 "Organic Chemical" @default.
- NCIT_C78194 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78194 NCIT_P107 "Ponatinib Hydrochloride" @default.
- NCIT_C78194 NCIT_P108 "Ponatinib Hydrochloride" @default.
- NCIT_C78194 NCIT_P207 "C2981174" @default.
- NCIT_C78194 NCIT_P210 "1114544-31-8" @default.
- NCIT_C78194 NCIT_P319 "96R6PU3D8J" @default.
- NCIT_C78194 NCIT_P322 "CTRP" @default.
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- NCIT_C78194 NCIT_P322 "GDC" @default.
- NCIT_C78194 NCIT_P329 "595060" @default.
- NCIT_C78194 NCIT_P330 "595060" @default.
- NCIT_C78194 NCIT_P350 "C29H27F3N6O.ClH" @default.
- NCIT_C78194 NCIT_P366 "Multitargeted_Receptor_Tyrosine_Kinase_Inhibitor_AP24534" @default.
- NCIT_C78194 NCIT_P375 "Ponatinib Hydrochloride" @default.
- NCIT_C78194 NCIT_P399 "595060" @default.
- NCIT_C78194 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C78194 NCIT_R124 NCIT_C40702 @default.
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- NCIT_C78194 NCIT_R125 NCIT_C17133 @default.
- NCIT_C78194 NCIT_R125 NCIT_C17828 @default.
- NCIT_C78194 NCIT_R125 NCIT_C18081 @default.
- NCIT_C78194 NCIT_R125 NCIT_C20480 @default.
- NCIT_C78194 NCIT_R125 NCIT_C20751 @default.
- NCIT_C78194 NCIT_R125 NCIT_C40821 @default.
- NCIT_C78194 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C78194 referenceCount "2" @default.
- NCIT_C78194 hasExactSynonym "AP24534 HCl" @default.
- NCIT_C78194 hasExactSynonym "Benzamide, 3-(2-Imidazo(1,2-B)Pyridazin-3-Ylethynyl)-4-Methyl-N-(4-((4-Methyl-1- Piperazinyl)Methyl)-3-(Trifluoromethyl)Phenyl)-, Hydrochloride (1:1)" @default.
- NCIT_C78194 hasExactSynonym "Iclusig" @default.
- NCIT_C78194 hasExactSynonym "PONATINIB HYDROCHLORIDE" @default.
- NCIT_C78194 hasExactSynonym "Ponatinib Hydrochloride" @default.
- NCIT_C78194 inSubset NCIT_C116977 @default.
- NCIT_C78194 inSubset NCIT_C116978 @default.
- NCIT_C78194 inSubset NCIT_C128784 @default.
- NCIT_C78194 inSubset NCIT_C157711 @default.
- NCIT_C78194 inSubset NCIT_C157712 @default.
- NCIT_C78194 inSubset NCIT_C176424 @default.
- NCIT_C78194 inSubset NCIT_C177537 @default.
- NCIT_C78194 inSubset NCIT_C63923 @default.
- NCIT_C78194 type Class @default.
- NCIT_C78194 isDefinedBy ncit.owl @default.
- NCIT_C78194 label "Ponatinib Hydrochloride" @default.
- NCIT_C78194 subClassOf NCIT_C124800 @default.
- NCIT_C78194 subClassOf NCIT_C129824 @default.
- NCIT_C78194 subClassOf NCIT_C129825 @default.
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- NCIT_C78194 subClassOf NCIT_C1967 @default.
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- NCIT_C78194 subClassOf NCIT_C274 @default.
- NCIT_C78194 subClassOf NCIT_C471 @default.
- NCIT_C78194 subClassOf NCIT_C78194 @default.
- NCIT_C78194 subClassOf NCIT_C93259 @default.