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- NCIT_C78198 IAO_0000115 "An intravenous formulation containing E.coli-derived L-asparaginase II conjugated with succinimidyl carbonate monomethoxypolyethylene glycol (SC-PEG), with potential antineoplastic activity. Upon administration of calaspargase pegol, L-asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting cells of asparagine; asparagine depletion blocks protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle and ultimately induces tumor cell death. Asparagine is critical to protein synthesis in acute lymphoblastic leukemia (ALL) cells which, unlike normal cells, cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Pegylation decreases enzyme antigenicity and increases its half life. SC is used as a PEG linker to facilitate attachment to asparaginase and enhances the stability of the formulation." @default.
- NCIT_C78198 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78198 NCIT_NHC0 "C78198" @default.
- NCIT_C78198 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78198 NCIT_P107 "Calaspargase Pegol" @default.
- NCIT_C78198 NCIT_P108 "Calaspargase Pegol" @default.
- NCIT_C78198 NCIT_P207 "C2699709" @default.
- NCIT_C78198 NCIT_P210 "941577-06-6" @default.
- NCIT_C78198 NCIT_P302 "acute lymphoblastic leukemia (ALL)" @default.
- NCIT_C78198 NCIT_P319 "T9FVH03HMZ" @default.
- NCIT_C78198 NCIT_P322 "CTRP" @default.
- NCIT_C78198 NCIT_P322 "FDA" @default.
- NCIT_C78198 NCIT_P322 "GDC" @default.
- NCIT_C78198 NCIT_P325 "A drug used to treat acute lymphoblastic leukemia (ALL). It is a form of the anticancer drug PEG-asparaginase that stays in the body longer. EZN-2285 is an enzyme that breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow. It is a type of protein synthesis inhibitor." @default.
- NCIT_C78198 NCIT_P329 "595298" @default.
- NCIT_C78198 NCIT_P330 "595298" @default.
- NCIT_C78198 NCIT_P366 "Succinimidyl_Carbonate_Monomethoxypolyethylene_Glycol_E_Coli_L-Asparaginase" @default.
- NCIT_C78198 NCIT_P375 "Calaspargase Pegol-mknl" @default.
- NCIT_C78198 NCIT_P399 "595298" @default.
- NCIT_C78198 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C78198 referenceCount "2" @default.
- NCIT_C78198 hasExactSynonym "Asparaginase (Escherichia coli Isoenzyme II), Conjugate with alpha-(((2,5-Dioxo-1-pyrrolidinyl)oxy)carbonyl)-omega-methoxypoly(oxy-1,2-ethanediyl)" @default.
- NCIT_C78198 hasExactSynonym "Asparlas" @default.
- NCIT_C78198 hasExactSynonym "CALASPARGASE PEGOL" @default.
- NCIT_C78198 hasExactSynonym "Calaspargase Pegol" @default.
- NCIT_C78198 hasExactSynonym "Calaspargase Pegol-mknl" @default.
- NCIT_C78198 hasExactSynonym "EZN-2285" @default.
- NCIT_C78198 hasExactSynonym "SC-PEG E. Coli L-Asparaginase" @default.
- NCIT_C78198 hasExactSynonym "SC-PEG E. coli L-asparaginase" @default.
- NCIT_C78198 hasExactSynonym "Succinimidyl Carbonate Monomethoxypolyethylene Glycol E. coli L-Asparaginase" @default.
- NCIT_C78198 inSubset NCIT_C116977 @default.
- NCIT_C78198 inSubset NCIT_C116978 @default.
- NCIT_C78198 inSubset NCIT_C128784 @default.
- NCIT_C78198 inSubset NCIT_C157711 @default.
- NCIT_C78198 inSubset NCIT_C157712 @default.
- NCIT_C78198 inSubset NCIT_C176424 @default.
- NCIT_C78198 inSubset NCIT_C177537 @default.
- NCIT_C78198 inSubset NCIT_C63923 @default.
- NCIT_C78198 type Class @default.
- NCIT_C78198 isDefinedBy ncit.owl @default.
- NCIT_C78198 label "Calaspargase Pegol" @default.
- NCIT_C78198 subClassOf NCIT_C1908 @default.
- NCIT_C78198 subClassOf NCIT_C1909 @default.
- NCIT_C78198 subClassOf NCIT_C29726 @default.
- NCIT_C78198 subClassOf NCIT_C307 @default.
- NCIT_C78198 subClassOf NCIT_C78198 @default.