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- NCIT_C78450 IAO_0000115 "A proprietary transferrin receptor-targeted nanoparticle preparation of a non-chemically modified small-interfering RNA (siRNA) directed against the M2 subunit of ribonucleotide reductase (RRM2) with potential antineoplastic activity. Upon administration, transferrin receptor-targeted anti-RRM2 siRNA CALAA-01 binds to transferrin receptors (TfRs), releasing anti-RRM2 siRNA after endocytosis; anti-RRM2 siRNA silences the expression of RRM2 via the RNAi pathway, impeding the assembly of the holoenzyme ribonucleotide reductase (RR) which catalyzes the production of deoxyribonucleotides. As a result, inhibition of cellular proliferation may occur in cells expressing TfR, a cell surface protein overexpressed on various cancer cell types." @default.
- NCIT_C78450 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78450 NCIT_A7 NCIT_C17079 @default.
- NCIT_C78450 NCIT_NHC0 "C78450" @default.
- NCIT_C78450 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78450 NCIT_P107 "Transferrin Receptor-Targeted Anti-RRM2 siRNA CALAA-01" @default.
- NCIT_C78450 NCIT_P108 "Transferrin Receptor-Targeted Anti-RRM2 siRNA CALAA-01" @default.
- NCIT_C78450 NCIT_P207 "C2703116" @default.
- NCIT_C78450 NCIT_P322 "CTRP" @default.
- NCIT_C78450 NCIT_P322 "GDC" @default.
- NCIT_C78450 NCIT_P329 "599463" @default.
- NCIT_C78450 NCIT_P330 "599463" @default.
- NCIT_C78450 NCIT_P366 "Transferrin_Receptor-Targeted_Nanocomplexed_Anti-R2_siRNA_CALAA-01" @default.
- NCIT_C78450 NCIT_P375 "Transferrin Receptor-Targeted Anti-RRM2 siRNA CALAA-01" @default.
- NCIT_C78450 NCIT_P399 "599463" @default.
- NCIT_C78450 normalizedInformationContent "100" @default.
- NCIT_C78450 referenceCount "1" @default.
- NCIT_C78450 hasExactSynonym "CALAA-01" @default.
- NCIT_C78450 hasExactSynonym "Transferrin Receptor-Targeted Anti-RRM2 siRNA CALAA-01" @default.
- NCIT_C78450 inSubset NCIT_C116977 @default.
- NCIT_C78450 inSubset NCIT_C116978 @default.
- NCIT_C78450 inSubset NCIT_C128784 @default.
- NCIT_C78450 inSubset NCIT_C157711 @default.
- NCIT_C78450 inSubset NCIT_C157712 @default.
- NCIT_C78450 inSubset NCIT_C176424 @default.
- NCIT_C78450 inSubset NCIT_C177537 @default.
- NCIT_C78450 type Class @default.
- NCIT_C78450 isDefinedBy ncit.owl @default.
- NCIT_C78450 label "Transferrin Receptor-Targeted Anti-RRM2 siRNA CALAA-01" @default.
- NCIT_C78450 subClassOf NCIT_C129821 @default.
- NCIT_C78450 subClassOf NCIT_C1908 @default.
- NCIT_C78450 subClassOf NCIT_C1909 @default.
- NCIT_C78450 subClassOf NCIT_C274 @default.
- NCIT_C78450 subClassOf NCIT_C307 @default.
- NCIT_C78450 subClassOf NCIT_C78450 @default.