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- NCIT_C78451 IAO_0000115 "A recombinant fusion protein consisting of de-immunized and humanized anti-CD20 monoclonal antibody Leu16 fused to human cytokine interleukin-2 (IL2) with potential antineoplastic activity. The antibody moiety of DI-Leu16-IL2 immunocytokine binds to tumor cells expressing the CD20 antigen, which may result in an antibody-dependent cell-mediated cytotoxicity (ADCC) towards CD20-expressing tumor cells; the localized IL2 moiety of this fusion protein may stimulate natural killer (NK) and T-lymphocyte mediated immune responses, enhancing the ADCC response. De-immunization involves the modification of potential helper T cell epitopes that bind to MHC class II molecules; humanization involves combining recombinant murine variable (V) regions with human immunoglobulin light and heavy chain constant regions. CD20 antigen, a hydrophobic transmembrane protein located on normal pre-B and mature B lymphocytes, is overexpressed by various cancer cell types." @default.
- NCIT_C78451 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78451 NCIT_A7 NCIT_C104679 @default.
- NCIT_C78451 NCIT_A7 NCIT_C38896 @default.
- NCIT_C78451 NCIT_NHC0 "C78451" @default.
- NCIT_C78451 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C78451 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78451 NCIT_P107 "DI-Leu16-IL2 Immunocytokine" @default.
- NCIT_C78451 NCIT_P108 "DI-Leu16-IL2 Immunocytokine" @default.
- NCIT_C78451 NCIT_P208 "CL387463" @default.
- NCIT_C78451 NCIT_P319 "8PQK3QPW4P" @default.
- NCIT_C78451 NCIT_P322 "CTRP" @default.
- NCIT_C78451 NCIT_P322 "FDA" @default.
- NCIT_C78451 NCIT_P322 "GDC" @default.
- NCIT_C78451 NCIT_P329 "599668" @default.
- NCIT_C78451 NCIT_P330 "599668" @default.
- NCIT_C78451 NCIT_P366 "De-Immunized_DI-Leu16-IL2_Immunocytokine" @default.
- NCIT_C78451 NCIT_P375 "DI-Leu16-IL2 Immunocytokine" @default.
- NCIT_C78451 NCIT_P399 "599668" @default.
- NCIT_C78451 normalizedInformationContent "100" @default.
- NCIT_C78451 referenceCount "1" @default.
- NCIT_C78451 hasExactSynonym "DI-LEU16-IL2" @default.
- NCIT_C78451 hasExactSynonym "DI-Leu16-IL-2" @default.
- NCIT_C78451 hasExactSynonym "DI-Leu16-IL2 Immunocytokine" @default.
- NCIT_C78451 hasExactSynonym "De-Immunized Anti-CD20-IL-2 Immunocytokine DI-Leu16-IL-2" @default.
- NCIT_C78451 inSubset NCIT_C116977 @default.
- NCIT_C78451 inSubset NCIT_C116978 @default.
- NCIT_C78451 inSubset NCIT_C128784 @default.
- NCIT_C78451 inSubset NCIT_C157711 @default.
- NCIT_C78451 inSubset NCIT_C157712 @default.
- NCIT_C78451 inSubset NCIT_C176424 @default.
- NCIT_C78451 inSubset NCIT_C177537 @default.
- NCIT_C78451 inSubset NCIT_C63923 @default.
- NCIT_C78451 type Class @default.
- NCIT_C78451 isDefinedBy ncit.owl @default.
- NCIT_C78451 label "DI-Leu16-IL2 Immunocytokine" @default.
- NCIT_C78451 subClassOf NCIT_C1512 @default.
- NCIT_C78451 subClassOf NCIT_C1908 @default.
- NCIT_C78451 subClassOf NCIT_C1909 @default.
- NCIT_C78451 subClassOf NCIT_C307 @default.
- NCIT_C78451 subClassOf NCIT_C308 @default.
- NCIT_C78451 subClassOf NCIT_C78451 @default.