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- NCIT_C78460 IAO_0000115 "An orally bioavailable recombinant human lactoferrin produced in the fungus Aspergillus niger with potential antineoplastic and immunomodulating activities. Upon oral administration, talactoferrin is transported into small intestinal Peyer's patches of the gut-associated lymphoreticular tissues (GALT), where it recruits circulating immature dendritic cells (DCs) bearing tumor antigens and induces their maturation. In the GALT, DC maturation in the presence of tumor antigens and lymphoid effector cells may induce systemic innate and adaptive immune responses mediated by anti-tumor natural killer (NK) cells, cytotoxic T lymphocytes, and natural killer T (NKT) cells; activation of tumor-draining lymph nodes, cellular infiltration of distant tumors, and tumor-cell death may follow. Raising the initial immune response in the GALT, distant from the primary tumor, may counter local tumor-mediated immunosuppression." @default.
- NCIT_C78460 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78460 NCIT_NHC0 "C78460" @default.
- NCIT_C78460 NCIT_P106 "Organic Chemical" @default.
- NCIT_C78460 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78460 NCIT_P107 "Talactoferrin Alfa" @default.
- NCIT_C78460 NCIT_P108 "Talactoferrin Alfa" @default.
- NCIT_C78460 NCIT_P207 "C1872514" @default.
- NCIT_C78460 NCIT_P210 "308240-58-6" @default.
- NCIT_C78460 NCIT_P302 "renal cell carcinoma" @default.
- NCIT_C78460 NCIT_P319 "7A055A9QRR" @default.
- NCIT_C78460 NCIT_P322 "CTRP" @default.
- NCIT_C78460 NCIT_P322 "FDA" @default.
- NCIT_C78460 NCIT_P322 "GDC" @default.
- NCIT_C78460 NCIT_P325 "A drug being studied in the treatment of kidney cancer that has spread. It is also being studied in the treatment of other types of cancer and other conditions. Talactoferrin increases the activity of dendritic cells (a type of immune cell) to help kill cancer cells. It is a form of human lactoferrin (a protein found in milk, tears, mucus, bile, and some white blood cells) that is made in the laboratory. Talactoferrin is a type of recombinant protein and a type of immunomodulatory protein." @default.
- NCIT_C78460 NCIT_P329 "394101" @default.
- NCIT_C78460 NCIT_P330 "394101" @default.
- NCIT_C78460 NCIT_P366 "Talactoferrin" @default.
- NCIT_C78460 NCIT_P375 "Talactoferrin Alfa" @default.
- NCIT_C78460 NCIT_P399 "394101" @default.
- NCIT_C78460 normalizedInformationContent "100" @default.
- NCIT_C78460 referenceCount "1" @default.
- NCIT_C78460 hasExactSynonym "Oral Recombinant Human Lactoferrin" @default.
- NCIT_C78460 hasExactSynonym "Oral rhLF" @default.
- NCIT_C78460 hasExactSynonym "TALACTOFERRIN ALFA" @default.
- NCIT_C78460 hasExactSynonym "TLF" @default.
- NCIT_C78460 hasExactSynonym "Talactoferrin Alfa" @default.
- NCIT_C78460 hasExactSynonym "talactoferrin alfa" @default.
- NCIT_C78460 hasExactSynonym "talactoferrin" @default.
- NCIT_C78460 inSubset NCIT_C116977 @default.
- NCIT_C78460 inSubset NCIT_C116978 @default.
- NCIT_C78460 inSubset NCIT_C128784 @default.
- NCIT_C78460 inSubset NCIT_C157711 @default.
- NCIT_C78460 inSubset NCIT_C157712 @default.
- NCIT_C78460 inSubset NCIT_C176424 @default.
- NCIT_C78460 inSubset NCIT_C177537 @default.
- NCIT_C78460 inSubset NCIT_C63923 @default.
- NCIT_C78460 type Class @default.
- NCIT_C78460 isDefinedBy ncit.owl @default.
- NCIT_C78460 label "Talactoferrin Alfa" @default.
- NCIT_C78460 subClassOf NCIT_C1908 @default.
- NCIT_C78460 subClassOf NCIT_C1909 @default.
- NCIT_C78460 subClassOf NCIT_C2139 @default.
- NCIT_C78460 subClassOf NCIT_C308 @default.
- NCIT_C78460 subClassOf NCIT_C78460 @default.