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- NCIT_C78475 IAO_0000115 "An orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC), with potential antineoplastic activity. Nanatinostat targets and inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins." @default.
- NCIT_C78475 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78475 NCIT_A7 NCIT_C16682 @default.
- NCIT_C78475 NCIT_NHC0 "C78475" @default.
- NCIT_C78475 NCIT_P106 "Organic Chemical" @default.
- NCIT_C78475 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78475 NCIT_P107 "Nanatinostat" @default.
- NCIT_C78475 NCIT_P108 "Nanatinostat" @default.
- NCIT_C78475 NCIT_P207 "C2703120" @default.
- NCIT_C78475 NCIT_P210 "1235859-13-8" @default.
- NCIT_C78475 NCIT_P319 "YTL7A418KQ" @default.
- NCIT_C78475 NCIT_P322 "CTRP" @default.
- NCIT_C78475 NCIT_P322 "FDA" @default.
- NCIT_C78475 NCIT_P322 "GDC" @default.
- NCIT_C78475 NCIT_P329 "600512" @default.
- NCIT_C78475 NCIT_P330 "600512" @default.
- NCIT_C78475 NCIT_P366 "HDAC_Inhibitor_CHR-3996" @default.
- NCIT_C78475 NCIT_P375 "Nanatinostat" @default.
- NCIT_C78475 NCIT_P399 "600512" @default.
- NCIT_C78475 normalizedInformationContent "100" @default.
- NCIT_C78475 referenceCount "1" @default.
- NCIT_C78475 hasExactSynonym "5-Pyrimidinecarboxamide, 2-((1Alpha,5alpha,6alpha)-6-(((6-fluoro-2-quinolinyl)methyl)amino)-3-azabicyclo(3.1.0)hex-3-yl)-N-hydroxy-" @default.
- NCIT_C78475 hasExactSynonym "CHR 3996" @default.
- NCIT_C78475 hasExactSynonym "CHR-3996" @default.
- NCIT_C78475 hasExactSynonym "HDAC Inhibitor VRx-3996" @default.
- NCIT_C78475 hasExactSynonym "Histone Deacetylase Inhibitor VRx-3996" @default.
- NCIT_C78475 hasExactSynonym "NANATINOSTAT" @default.
- NCIT_C78475 hasExactSynonym "Nanatinostat" @default.
- NCIT_C78475 hasExactSynonym "VRx 3996" @default.
- NCIT_C78475 hasExactSynonym "VRx-3996" @default.
- NCIT_C78475 hasExactSynonym "VRx3996" @default.
- NCIT_C78475 hasExactSynonym "WHO 10911" @default.
- NCIT_C78475 inSubset NCIT_C116977 @default.
- NCIT_C78475 inSubset NCIT_C116978 @default.
- NCIT_C78475 inSubset NCIT_C128784 @default.
- NCIT_C78475 inSubset NCIT_C157711 @default.
- NCIT_C78475 inSubset NCIT_C157712 @default.
- NCIT_C78475 inSubset NCIT_C176424 @default.
- NCIT_C78475 inSubset NCIT_C177537 @default.
- NCIT_C78475 inSubset NCIT_C63923 @default.
- NCIT_C78475 type Class @default.
- NCIT_C78475 isDefinedBy ncit.owl @default.
- NCIT_C78475 label "Nanatinostat" @default.
- NCIT_C78475 subClassOf NCIT_C129824 @default.
- NCIT_C78475 subClassOf NCIT_C129825 @default.
- NCIT_C78475 subClassOf NCIT_C163758 @default.
- NCIT_C78475 subClassOf NCIT_C1908 @default.
- NCIT_C78475 subClassOf NCIT_C1909 @default.
- NCIT_C78475 subClassOf NCIT_C1946 @default.
- NCIT_C78475 subClassOf NCIT_C2189 @default.
- NCIT_C78475 subClassOf NCIT_C274 @default.
- NCIT_C78475 subClassOf NCIT_C471 @default.
- NCIT_C78475 subClassOf NCIT_C78475 @default.