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- NCIT_C78476 IAO_0000115 "An orally bioavailable mammalian target of rapamycin (mTOR) kinase inhibitor, with potential antineoplastic activity. Upon oral administration, mTOR kinase inhibitor CERC-006 binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR is a serine/threonine kinase that is upregulated in some tumors and plays an important role downstream in the PI3K/Akt/mTOR signaling pathway." @default.
- NCIT_C78476 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78476 NCIT_A7 NCIT_C96314 @default.
- NCIT_C78476 NCIT_A7 NCIT_C96315 @default.
- NCIT_C78476 NCIT_NHC0 "C78476" @default.
- NCIT_C78476 NCIT_P106 "Organic Chemical" @default.
- NCIT_C78476 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78476 NCIT_P107 "mTOR Kinase Inhibitor CERC-006" @default.
- NCIT_C78476 NCIT_P108 "mTOR Kinase Inhibitor CERC-006" @default.
- NCIT_C78476 NCIT_P207 "C2703121" @default.
- NCIT_C78476 NCIT_P210 "936890-98-1" @default.
- NCIT_C78476 NCIT_P319 "25MKH1SZ0M" @default.
- NCIT_C78476 NCIT_P322 "CTRP" @default.
- NCIT_C78476 NCIT_P322 "FDA" @default.
- NCIT_C78476 NCIT_P322 "GDC" @default.
- NCIT_C78476 NCIT_P329 "600513" @default.
- NCIT_C78476 NCIT_P330 "600513" @default.
- NCIT_C78476 NCIT_P366 "mTOR_Kinase_Inhibitor_OSI-027" @default.
- NCIT_C78476 NCIT_P375 "mTOR Kinase Inhibitor OSI-027" @default.
- NCIT_C78476 NCIT_P399 "600513" @default.
- NCIT_C78476 normalizedInformationContent "100" @default.
- NCIT_C78476 referenceCount "1" @default.
- NCIT_C78476 hasExactSynonym "AEVI 006" @default.
- NCIT_C78476 hasExactSynonym "AEVI-006" @default.
- NCIT_C78476 hasExactSynonym "AEVI006" @default.
- NCIT_C78476 hasExactSynonym "ASP 7486" @default.
- NCIT_C78476 hasExactSynonym "ASP-7486" @default.
- NCIT_C78476 hasExactSynonym "ASP7486" @default.
- NCIT_C78476 hasExactSynonym "CERC 006" @default.
- NCIT_C78476 hasExactSynonym "CERC-006" @default.
- NCIT_C78476 hasExactSynonym "CERC006" @default.
- NCIT_C78476 hasExactSynonym "Mammalian Target of Rapamycin Kinase Inhibitor OSI-027" @default.
- NCIT_C78476 hasExactSynonym "OSI-027" @default.
- NCIT_C78476 hasExactSynonym "mTOR Kinase Inhibitor CERC-006" @default.
- NCIT_C78476 hasExactSynonym "mTOR Kinase Inhibitor OSI-027" @default.
- NCIT_C78476 inSubset NCIT_C116977 @default.
- NCIT_C78476 inSubset NCIT_C116978 @default.
- NCIT_C78476 inSubset NCIT_C128784 @default.
- NCIT_C78476 inSubset NCIT_C157711 @default.
- NCIT_C78476 inSubset NCIT_C157712 @default.
- NCIT_C78476 inSubset NCIT_C176424 @default.
- NCIT_C78476 inSubset NCIT_C177537 @default.
- NCIT_C78476 inSubset NCIT_C63923 @default.
- NCIT_C78476 type Class @default.
- NCIT_C78476 isDefinedBy ncit.owl @default.
- NCIT_C78476 label "mTOR Kinase Inhibitor CERC-006" @default.
- NCIT_C78476 subClassOf NCIT_C129824 @default.
- NCIT_C78476 subClassOf NCIT_C129825 @default.
- NCIT_C78476 subClassOf NCIT_C1404 @default.
- NCIT_C78476 subClassOf NCIT_C163758 @default.
- NCIT_C78476 subClassOf NCIT_C1908 @default.
- NCIT_C78476 subClassOf NCIT_C1909 @default.
- NCIT_C78476 subClassOf NCIT_C2189 @default.
- NCIT_C78476 subClassOf NCIT_C2201 @default.
- NCIT_C78476 subClassOf NCIT_C274 @default.
- NCIT_C78476 subClassOf NCIT_C471 @default.
- NCIT_C78476 subClassOf NCIT_C61074 @default.
- NCIT_C78476 subClassOf NCIT_C78476 @default.