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- NCIT_C78483 IAO_0000115 "An orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity. MET tyrosine kinase inhibitor PF-04217903 selectively binds to and inhibits c-Met, disrupting the c-Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction of death in tumor cells expressing c-Met. The receptor tyrosine kinase c-Met, also known as hepatocyte growth factor (HGF) receptor, is overexpressed or mutated in many tumor cell types, playing an important role in tumor cell proliferation, survival, invasion, and metastasis and angiogenesis." @default.
- NCIT_C78483 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78483 NCIT_A5 NCIT_C141443 @default.
- NCIT_C78483 NCIT_A7 NCIT_C18186 @default.
- NCIT_C78483 NCIT_NHC0 "C78483" @default.
- NCIT_C78483 NCIT_P106 "Organic Chemical" @default.
- NCIT_C78483 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78483 NCIT_P107 "MET Tyrosine Kinase Inhibitor PF-04217903" @default.
- NCIT_C78483 NCIT_P108 "MET Tyrosine Kinase Inhibitor PF-04217903" @default.
- NCIT_C78483 NCIT_P207 "C2703125" @default.
- NCIT_C78483 NCIT_P210 "956905-27-4" @default.
- NCIT_C78483 NCIT_P319 "CYJ9ATV1IJ" @default.
- NCIT_C78483 NCIT_P322 "CTRP" @default.
- NCIT_C78483 NCIT_P322 "FDA" @default.
- NCIT_C78483 NCIT_P322 "GDC" @default.
- NCIT_C78483 NCIT_P329 "601032" @default.
- NCIT_C78483 NCIT_P330 "601032" @default.
- NCIT_C78483 NCIT_P366 "MET_Tyrosine_Kinase_Inhibitor_PF-04217903" @default.
- NCIT_C78483 NCIT_P375 "MET Tyrosine Kinase Inhibitor PF-04217903" @default.
- NCIT_C78483 NCIT_P399 "601032" @default.
- NCIT_C78483 normalizedInformationContent "100" @default.
- NCIT_C78483 referenceCount "1" @default.
- NCIT_C78483 hasExactSynonym "2-(4-(1-(Quinolin-6-ylmethyl)-1H-(1,2,3)triazolo(4,5-b)pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol" @default.
- NCIT_C78483 hasExactSynonym "MET Tyrosine Kinase Inhibitor PF-04217903" @default.
- NCIT_C78483 hasExactSynonym "PF-04217903" @default.
- NCIT_C78483 inSubset NCIT_C116977 @default.
- NCIT_C78483 inSubset NCIT_C116978 @default.
- NCIT_C78483 inSubset NCIT_C128784 @default.
- NCIT_C78483 inSubset NCIT_C157711 @default.
- NCIT_C78483 inSubset NCIT_C157712 @default.
- NCIT_C78483 inSubset NCIT_C176424 @default.
- NCIT_C78483 inSubset NCIT_C177537 @default.
- NCIT_C78483 inSubset NCIT_C63923 @default.
- NCIT_C78483 type Class @default.
- NCIT_C78483 isDefinedBy ncit.owl @default.
- NCIT_C78483 label "MET Tyrosine Kinase Inhibitor PF-04217903" @default.
- NCIT_C78483 subClassOf NCIT_C129824 @default.
- NCIT_C78483 subClassOf NCIT_C129825 @default.
- NCIT_C78483 subClassOf NCIT_C1404 @default.
- NCIT_C78483 subClassOf NCIT_C143099 @default.
- NCIT_C78483 subClassOf NCIT_C163758 @default.
- NCIT_C78483 subClassOf NCIT_C164000 @default.
- NCIT_C78483 subClassOf NCIT_C1908 @default.
- NCIT_C78483 subClassOf NCIT_C1909 @default.
- NCIT_C78483 subClassOf NCIT_C1967 @default.
- NCIT_C78483 subClassOf NCIT_C2189 @default.
- NCIT_C78483 subClassOf NCIT_C274 @default.
- NCIT_C78483 subClassOf NCIT_C471 @default.
- NCIT_C78483 subClassOf NCIT_C78483 @default.