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- NCIT_C78489 IAO_0000115 "A cancer vaccine comprised of autologous dendritic cells (DCs) pulsed with the marine sponge glycolipid alpha-galactosylceramide (alpha-GalCer) with potential immunostimulatory and antimetastatic activities. Upon administration, alpha-galactosylceramide-pulsed autologous dendritic cells may result in the activation and proliferation of a subset of endogenous natural killer T (NKT) cells, B cells, and CD4+ and CD8+ T cells, and the production of interferon-gamma and interleukin-12; these cascade events may result in a T helper-1 cell-biased proinflammatory antitumor immune response. The NKT cell ligand alpha-GalCer was originally isolated from the marine sponge Agelas mauritianusis." @default.
- NCIT_C78489 NCIT_NHC0 "C78489" @default.
- NCIT_C78489 NCIT_P106 "Cell" @default.
- NCIT_C78489 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78489 NCIT_P108 "Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells" @default.
- NCIT_C78489 NCIT_P208 "CL387518" @default.
- NCIT_C78489 NCIT_P329 "600075" @default.
- NCIT_C78489 NCIT_P330 "600075" @default.
- NCIT_C78489 NCIT_P366 "Alpha-Galactosyl_Ceramide-Pulsed_Autologous_Dendritic_Cells" @default.
- NCIT_C78489 NCIT_P399 "600075" @default.
- NCIT_C78489 normalizedInformationContent "100" @default.
- NCIT_C78489 referenceCount "1" @default.
- NCIT_C78489 hasExactSynonym "Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells" @default.
- NCIT_C78489 hasExactSynonym "DC-KRN7000" @default.
- NCIT_C78489 hasExactSynonym "KRN7000-Pulsed Autologous Dendritic Cells" @default.
- NCIT_C78489 inSubset NCIT_C128784 @default.
- NCIT_C78489 inSubset NCIT_C176424 @default.
- NCIT_C78489 type Class @default.
- NCIT_C78489 isDefinedBy ncit.owl @default.
- NCIT_C78489 label "Alpha-Galactosylceramide-Pulsed Autologous Dendritic Cells" @default.
- NCIT_C78489 subClassOf NCIT_C129820 @default.
- NCIT_C78489 subClassOf NCIT_C129821 @default.
- NCIT_C78489 subClassOf NCIT_C129826 @default.
- NCIT_C78489 subClassOf NCIT_C142078 @default.
- NCIT_C78489 subClassOf NCIT_C1663 @default.
- NCIT_C78489 subClassOf NCIT_C1908 @default.
- NCIT_C78489 subClassOf NCIT_C1909 @default.
- NCIT_C78489 subClassOf NCIT_C274 @default.
- NCIT_C78489 subClassOf NCIT_C28308 @default.
- NCIT_C78489 subClassOf NCIT_C28310 @default.
- NCIT_C78489 subClassOf NCIT_C307 @default.
- NCIT_C78489 subClassOf NCIT_C308 @default.
- NCIT_C78489 subClassOf NCIT_C78489 @default.
- NCIT_C78489 subClassOf NCIT_C923 @default.