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- NCIT_C788 IAO_0000115 "A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)" @default.
- NCIT_C788 NCIT_NHC0 "C788" @default.
- NCIT_C788 NCIT_P106 "Organic Chemical" @default.
- NCIT_C788 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C788 NCIT_P107 "Pyrimethamine" @default.
- NCIT_C788 NCIT_P108 "Pyrimethamine" @default.
- NCIT_C788 NCIT_P175 "3061" @default.
- NCIT_C788 NCIT_P207 "C0034283" @default.
- NCIT_C788 NCIT_P210 "58-14-0" @default.
- NCIT_C788 NCIT_P319 "Z3614QOX8W" @default.
- NCIT_C788 NCIT_P322 "CTRP" @default.
- NCIT_C788 NCIT_P322 "FDA" @default.
- NCIT_C788 NCIT_P329 "39578" @default.
- NCIT_C788 NCIT_P330 "39578" @default.
- NCIT_C788 NCIT_P350 "C12H13ClN4" @default.
- NCIT_C788 NCIT_P366 "Pyrimethamine" @default.
- NCIT_C788 NCIT_P368 "CHEBI:8673" @default.
- NCIT_C788 NCIT_P399 "39578" @default.
- NCIT_C788 normalizedInformationContent "100" @default.
- NCIT_C788 referenceCount "1" @default.
- NCIT_C788 hasExactSynonym "Daraprim" @default.
- NCIT_C788 hasExactSynonym "PYRIMETHAMINE" @default.
- NCIT_C788 hasExactSynonym "Pyrimethamine" @default.
- NCIT_C788 inSubset NCIT_C116977 @default.
- NCIT_C788 inSubset NCIT_C116978 @default.
- NCIT_C788 inSubset NCIT_C176424 @default.
- NCIT_C788 inSubset NCIT_C63923 @default.
- NCIT_C788 type Class @default.
- NCIT_C788 isDefinedBy ncit.owl @default.
- NCIT_C788 label "Pyrimethamine" @default.
- NCIT_C788 subClassOf NCIT_C1908 @default.
- NCIT_C788 subClassOf NCIT_C1909 @default.
- NCIT_C788 subClassOf NCIT_C2153 @default.
- NCIT_C788 subClassOf NCIT_C254 @default.
- NCIT_C788 subClassOf NCIT_C271 @default.
- NCIT_C788 subClassOf NCIT_C276 @default.
- NCIT_C788 subClassOf NCIT_C277 @default.
- NCIT_C788 subClassOf NCIT_C471 @default.
- NCIT_C788 subClassOf NCIT_C788 @default.