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- NCIT_C78822 IAO_0000115 "A double-stranded 15-mer oligonucleotide, corresponding closely to the signal transducer and activator of transcription 3 (STAT3) response element within the c-fos promoter, with potential antineoplastic activity. STAT3 decoy oligonucleotide binds specifically to activated STAT3 and blocks binding of STAT3 to DNA sequences on a variety of STAT3-responsive promoters, which results in the inhibition of STAT3-mediated transcription and, potentially, the inhibition of tumor cell proliferation. STAT3 is constitutively activated in a variety of cancers including squamous cell carcinoma of the head and neck, contributing to the loss of cell growth control and neoplastic transformation." @default.
- NCIT_C78822 NCIT_NHC0 "C78822" @default.
- NCIT_C78822 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78822 NCIT_P108 "STAT3 Decoy Oligonucleotide" @default.
- NCIT_C78822 NCIT_P208 "CL387640" @default.
- NCIT_C78822 NCIT_P329 "601204" @default.
- NCIT_C78822 NCIT_P330 "601204" @default.
- NCIT_C78822 NCIT_P366 "STAT3_Decoy_Oligonucleotide" @default.
- NCIT_C78822 NCIT_P399 "601204" @default.
- NCIT_C78822 normalizedInformationContent "100" @default.
- NCIT_C78822 referenceCount "1" @default.
- NCIT_C78822 hasExactSynonym "STAT3 Decoy ODN" @default.
- NCIT_C78822 hasExactSynonym "STAT3 Decoy Oligonucleotide" @default.
- NCIT_C78822 hasExactSynonym "STAT3 Decoy" @default.
- NCIT_C78822 inSubset NCIT_C128784 @default.
- NCIT_C78822 inSubset NCIT_C176424 @default.
- NCIT_C78822 type Class @default.
- NCIT_C78822 isDefinedBy ncit.owl @default.
- NCIT_C78822 label "STAT3 Decoy Oligonucleotide" @default.
- NCIT_C78822 subClassOf NCIT_C1291 @default.
- NCIT_C78822 subClassOf NCIT_C1908 @default.
- NCIT_C78822 subClassOf NCIT_C1909 @default.
- NCIT_C78822 subClassOf NCIT_C1962 @default.
- NCIT_C78822 subClassOf NCIT_C307 @default.
- NCIT_C78822 subClassOf NCIT_C78822 @default.