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- NCIT_C78823 IAO_0000115 "A preparation of autologous peripheral blood T-lymphocytes (PBTL) that have been genetically modified to express the chimeric antigen receptor (CAR) anti-CD19/CD3 zeta chain fusion protein coupled to the intracellular signal domain of CD28 antigen, with potential immunostimulating and antineoplastic activities. Upon administration, autologous PBTL CD19CAR-28 zeta may stimulate host cytotoxic T lymphocyte (CTL) and antibody responses against CD19-expressing tumor cells, resulting in tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the T-cell receptor (TCR)/CD3 complex and regulates the assembly of complete TCR complexes and their expression on the cell surface. CD28 is essential for CD4+ T-cell proliferation, interleukin-2 production, and T-helper type-2 (Th2) development." @default.
- NCIT_C78823 NCIT_A7 NCIT_C38894 @default.
- NCIT_C78823 NCIT_NHC0 "C78823" @default.
- NCIT_C78823 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78823 NCIT_P107 "Autologous PBTL CD19CAR-28 zeta" @default.
- NCIT_C78823 NCIT_P108 "Autologous PBTL CD19CAR-28 zeta" @default.
- NCIT_C78823 NCIT_P207 "C2981181" @default.
- NCIT_C78823 NCIT_P322 "CTRP" @default.
- NCIT_C78823 NCIT_P329 "601215" @default.
- NCIT_C78823 NCIT_P330 "601215" @default.
- NCIT_C78823 NCIT_P366 "PBTL_CD19CAR-28zeta" @default.
- NCIT_C78823 NCIT_P399 "601215" @default.
- NCIT_C78823 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C78823 NCIT_R125 NCIT_C17828 @default.
- NCIT_C78823 NCIT_R125 NCIT_C17937 @default.
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- NCIT_C78823 NCIT_R125 NCIT_C26280 @default.
- NCIT_C78823 NCIT_R125 NCIT_C40833 @default.
- NCIT_C78823 NCIT_R125 NCIT_C40912 @default.
- NCIT_C78823 NCIT_R72 NCIT_C104083 @default.
- NCIT_C78823 NCIT_R72 NCIT_C12219 @default.
- NCIT_C78823 NCIT_R72 NCIT_C12476 @default.
- NCIT_C78823 NCIT_R72 NCIT_C12508 @default.
- NCIT_C78823 NCIT_R72 NCIT_C12535 @default.
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- NCIT_C78823 NCIT_R72 NCIT_C12543 @default.
- NCIT_C78823 NCIT_R72 NCIT_C21599 @default.
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- NCIT_C78823 NCIT_R72 NCIT_C33061 @default.
- NCIT_C78823 NCIT_R72 NCIT_C38434 @default.
- NCIT_C78823 NCIT_R72 NCIT_C38439 @default.
- NCIT_C78823 NCIT_R72 NCIT_C39567 @default.
- NCIT_C78823 NCIT_R72 NCIT_C39568 @default.
- NCIT_C78823 normalizedInformationContent "100" @default.
- NCIT_C78823 referenceCount "1" @default.
- NCIT_C78823 hasExactSynonym "Autologous PBTL CD19CAR-28 zeta" @default.
- NCIT_C78823 hasExactSynonym "Autologous Peripheral Blood T-Lymphocytes CD19CAR-28 zeta" @default.
- NCIT_C78823 inSubset NCIT_C116977 @default.
- NCIT_C78823 inSubset NCIT_C116978 @default.
- NCIT_C78823 inSubset NCIT_C128784 @default.
- NCIT_C78823 inSubset NCIT_C176424 @default.
- NCIT_C78823 type Class @default.
- NCIT_C78823 isDefinedBy ncit.owl @default.
- NCIT_C78823 label "Autologous PBTL CD19CAR-28 zeta" @default.
- NCIT_C78823 subClassOf NCIT_C129820 @default.
- NCIT_C78823 subClassOf NCIT_C129821 @default.
- NCIT_C78823 subClassOf NCIT_C129826 @default.
- NCIT_C78823 subClassOf NCIT_C137999 @default.
- NCIT_C78823 subClassOf NCIT_C142078 @default.
- NCIT_C78823 subClassOf NCIT_C154231 @default.
- NCIT_C78823 subClassOf NCIT_C176018 @default.
- NCIT_C78823 subClassOf NCIT_C1908 @default.
- NCIT_C78823 subClassOf NCIT_C1909 @default.
- NCIT_C78823 subClassOf NCIT_C1962 @default.
- NCIT_C78823 subClassOf NCIT_C200766 @default.
- NCIT_C78823 subClassOf NCIT_C274 @default.
- NCIT_C78823 subClassOf NCIT_C28681 @default.
- NCIT_C78823 subClassOf NCIT_C307 @default.
- NCIT_C78823 subClassOf NCIT_C308 @default.
- NCIT_C78823 subClassOf NCIT_C78823 @default.