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- NCIT_C78824 IAO_0000115 "Autologous Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTL) that have been genetically modified to express a T-cell chimeric antigen receptor (CAR) targeting the CD19 antigen, with potential immunotherapeutic activity. The CAR consists of a single chain Fv of anti-CD19 IgG1 coupled with an intracellular signaling region of the zeta-chain of the TCR/CD3 complex (CD3 zeta). Autologous EBV-CTL CD19CAR zeta directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies." @default.
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- NCIT_C78824 NCIT_P108 "Autologous EBV-CTL CD19CAR zeta" @default.
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- NCIT_C78824 NCIT_P366 "EBV-CTL_CD19CARzeta" @default.
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- NCIT_C78824 hasExactSynonym "Autologous EBV-CTL CD19CAR zeta" @default.
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- NCIT_C78824 type Class @default.
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- NCIT_C78824 label "Autologous EBV-CTL CD19CAR zeta" @default.
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