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- NCIT_C78825 IAO_0000115 "An orally bioavailable, small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Idelalisib inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells." @default.
- NCIT_C78825 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78825 NCIT_A7 NCIT_C113631 @default.
- NCIT_C78825 NCIT_NHC0 "C78825" @default.
- NCIT_C78825 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78825 NCIT_P107 "Idelalisib" @default.
- NCIT_C78825 NCIT_P108 "Idelalisib" @default.
- NCIT_C78825 NCIT_P207 "C2698692" @default.
- NCIT_C78825 NCIT_P210 "870281-82-6" @default.
- NCIT_C78825 NCIT_P302 "relapsed chronic lymphocytic leukemia (CLL)" @default.
- NCIT_C78825 NCIT_P319 "YG57I8T5M0" @default.
- NCIT_C78825 NCIT_P322 "CTRP" @default.
- NCIT_C78825 NCIT_P322 "FDA" @default.
- NCIT_C78825 NCIT_P322 "GDC" @default.
- NCIT_C78825 NCIT_P329 "601486" @default.
- NCIT_C78825 NCIT_P330 "601486" @default.
- NCIT_C78825 NCIT_P366 "PI3K-delta_Inhibitor_CAL-101" @default.
- NCIT_C78825 NCIT_P375 "Idelalisib" @default.
- NCIT_C78825 NCIT_P399 "601486" @default.
- NCIT_C78825 normalizedInformationContent "90.826665450122817" @default.
- NCIT_C78825 referenceCount "4" @default.
- NCIT_C78825 hasExactSynonym "5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H- quinazolin-4-one" @default.
- NCIT_C78825 hasExactSynonym "CAL-101" @default.
- NCIT_C78825 hasExactSynonym "GS 1101" @default.
- NCIT_C78825 hasExactSynonym "GS-1101" @default.
- NCIT_C78825 hasExactSynonym "IDELALISIB" @default.
- NCIT_C78825 hasExactSynonym "Idelalisib" @default.
- NCIT_C78825 hasExactSynonym "Phosphoinositide-3 Kinase Delta Inhibitor CAL-101" @default.
- NCIT_C78825 hasExactSynonym "Zydelig" @default.
- NCIT_C78825 inSubset NCIT_C116977 @default.
- NCIT_C78825 inSubset NCIT_C116978 @default.
- NCIT_C78825 inSubset NCIT_C128784 @default.
- NCIT_C78825 inSubset NCIT_C157711 @default.
- NCIT_C78825 inSubset NCIT_C157712 @default.
- NCIT_C78825 inSubset NCIT_C176424 @default.
- NCIT_C78825 inSubset NCIT_C177537 @default.
- NCIT_C78825 inSubset NCIT_C63923 @default.
- NCIT_C78825 type Class @default.
- NCIT_C78825 isDefinedBy ncit.owl @default.
- NCIT_C78825 label "Idelalisib" @default.
- NCIT_C78825 subClassOf NCIT_C129824 @default.
- NCIT_C78825 subClassOf NCIT_C129825 @default.
- NCIT_C78825 subClassOf NCIT_C1404 @default.
- NCIT_C78825 subClassOf NCIT_C163758 @default.
- NCIT_C78825 subClassOf NCIT_C1742 @default.
- NCIT_C78825 subClassOf NCIT_C1908 @default.
- NCIT_C78825 subClassOf NCIT_C1909 @default.
- NCIT_C78825 subClassOf NCIT_C2152 @default.
- NCIT_C78825 subClassOf NCIT_C2189 @default.
- NCIT_C78825 subClassOf NCIT_C274 @default.
- NCIT_C78825 subClassOf NCIT_C471 @default.
- NCIT_C78825 subClassOf NCIT_C78825 @default.