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- NCIT_C78826 IAO_0000115 "An agonist mouse monoclonal antibody directed against TRAIL death receptor type 5 (DR5) with potential antineoplastic activity. Anti-DR5 agonist monoclonal antibody TRA-8 binds DR5, which may induce apoptosis in DR5-expressing tumor cells. DR5 is a tumor cell surface ligand that crosslinks with death receptor type 4 (DR4) when bound by TRAIL [Tumor necrosis (TNF)-related apoptosis-inducing ligand], triggering apoptosis via a death receptor signaling pathway. The apoptotic activity of this antibody may not require DR4/DR5 crosslinking." @default.
- NCIT_C78826 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78826 NCIT_NHC0 "C78826" @default.
- NCIT_C78826 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78826 NCIT_P108 "Anti-DR5 Agonist Monoclonal Antibody TRA-8" @default.
- NCIT_C78826 NCIT_P208 "CL387674" @default.
- NCIT_C78826 NCIT_P322 "GDC" @default.
- NCIT_C78826 NCIT_P329 "601797" @default.
- NCIT_C78826 NCIT_P330 "601797" @default.
- NCIT_C78826 NCIT_P366 "Anti-DR5_Agonist_Monoclonal_Antibody_TRA-8" @default.
- NCIT_C78826 NCIT_P375 "Anti-DR5 Agonist Monoclonal Antibody TRA-8" @default.
- NCIT_C78826 NCIT_P399 "601797" @default.
- NCIT_C78826 NCIT_R124 NCIT_C17710 @default.
- NCIT_C78826 NCIT_R124 NCIT_C17828 @default.
- NCIT_C78826 NCIT_R124 NCIT_C18219 @default.
- NCIT_C78826 NCIT_R124 NCIT_C19986 @default.
- NCIT_C78826 NCIT_R124 NCIT_C40474 @default.
- NCIT_C78826 normalizedInformationContent "100" @default.
- NCIT_C78826 referenceCount "1" @default.
- NCIT_C78826 hasExactSynonym "Anti-DR5 Agonist Monoclonal Antibody TRA-8" @default.
- NCIT_C78826 hasExactSynonym "Anti-death Receptor 5 Agonist Monoclonal Antibody TRA-8" @default.
- NCIT_C78826 hasExactSynonym "TRA-8" @default.
- NCIT_C78826 inSubset NCIT_C128784 @default.
- NCIT_C78826 inSubset NCIT_C157711 @default.
- NCIT_C78826 inSubset NCIT_C157712 @default.
- NCIT_C78826 inSubset NCIT_C176424 @default.
- NCIT_C78826 inSubset NCIT_C177537 @default.
- NCIT_C78826 type Class @default.
- NCIT_C78826 isDefinedBy ncit.owl @default.
- NCIT_C78826 label "Anti-DR5 Agonist Monoclonal Antibody TRA-8" @default.
- NCIT_C78826 subClassOf NCIT_C129821 @default.
- NCIT_C78826 subClassOf NCIT_C129822 @default.
- NCIT_C78826 subClassOf NCIT_C171189 @default.
- NCIT_C78826 subClassOf NCIT_C1908 @default.
- NCIT_C78826 subClassOf NCIT_C1909 @default.
- NCIT_C78826 subClassOf NCIT_C20401 @default.
- NCIT_C78826 subClassOf NCIT_C274 @default.
- NCIT_C78826 subClassOf NCIT_C307 @default.
- NCIT_C78826 subClassOf NCIT_C308 @default.
- NCIT_C78826 subClassOf NCIT_C574 @default.
- NCIT_C78826 subClassOf NCIT_C78826 @default.