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- NCIT_C78838 IAO_0000115 "A glycoengineered monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Imgatuzumab binds to the extracellular domain of EGFR, preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition of downstream ERK and JNK signaling pathways and so inhibition of EGFR-dependent tumor cell proliferation and metastasis. EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of various solid tumor cell types." @default.
- NCIT_C78838 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78838 NCIT_A7 NCIT_C17068 @default.
- NCIT_C78838 NCIT_NHC0 "C78838" @default.
- NCIT_C78838 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C78838 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78838 NCIT_P107 "Imgatuzumab" @default.
- NCIT_C78838 NCIT_P108 "Imgatuzumab" @default.
- NCIT_C78838 NCIT_P208 "CL387675" @default.
- NCIT_C78838 NCIT_P210 "959963-46-3" @default.
- NCIT_C78838 NCIT_P319 "V77J4WJF9Z" @default.
- NCIT_C78838 NCIT_P322 "CTRP" @default.
- NCIT_C78838 NCIT_P322 "FDA" @default.
- NCIT_C78838 NCIT_P322 "GDC" @default.
- NCIT_C78838 NCIT_P329 "609889" @default.
- NCIT_C78838 NCIT_P330 "609889" @default.
- NCIT_C78838 NCIT_P366 "Anti-EGFR_Monoclonal_Antibody_RO5083945" @default.
- NCIT_C78838 NCIT_P375 "Anti-EGFR Monoclonal Antibody RO5083945" @default.
- NCIT_C78838 NCIT_P375 "Imgatuzumab" @default.
- NCIT_C78838 NCIT_P399 "609889" @default.
- NCIT_C78838 NCIT_R124 NCIT_C17710 @default.
- NCIT_C78838 NCIT_R124 NCIT_C17828 @default.
- NCIT_C78838 NCIT_R124 NCIT_C18219 @default.
- NCIT_C78838 NCIT_R124 NCIT_C19986 @default.
- NCIT_C78838 NCIT_R124 NCIT_C40474 @default.
- NCIT_C78838 normalizedInformationContent "100" @default.
- NCIT_C78838 referenceCount "1" @default.
- NCIT_C78838 hasExactSynonym "Anti-Epidermal Growth Factor Receptor Monoclonal Antibody RO5083945" @default.
- NCIT_C78838 hasExactSynonym "GA-201" @default.
- NCIT_C78838 hasExactSynonym "GA201" @default.
- NCIT_C78838 hasExactSynonym "IMGATUZUMAB" @default.
- NCIT_C78838 hasExactSynonym "Imgatuzumab" @default.
- NCIT_C78838 hasExactSynonym "RG 7160" @default.
- NCIT_C78838 hasExactSynonym "RG-7160" @default.
- NCIT_C78838 hasExactSynonym "RG7160" @default.
- NCIT_C78838 inSubset NCIT_C116977 @default.
- NCIT_C78838 inSubset NCIT_C116978 @default.
- NCIT_C78838 inSubset NCIT_C128784 @default.
- NCIT_C78838 inSubset NCIT_C157711 @default.
- NCIT_C78838 inSubset NCIT_C157712 @default.
- NCIT_C78838 inSubset NCIT_C176424 @default.
- NCIT_C78838 inSubset NCIT_C177537 @default.
- NCIT_C78838 inSubset NCIT_C63923 @default.
- NCIT_C78838 type Class @default.
- NCIT_C78838 isDefinedBy ncit.owl @default.
- NCIT_C78838 label "Imgatuzumab" @default.
- NCIT_C78838 subClassOf NCIT_C129821 @default.
- NCIT_C78838 subClassOf NCIT_C129822 @default.
- NCIT_C78838 subClassOf NCIT_C133878 @default.
- NCIT_C78838 subClassOf NCIT_C163758 @default.
- NCIT_C78838 subClassOf NCIT_C163952 @default.
- NCIT_C78838 subClassOf NCIT_C1908 @default.
- NCIT_C78838 subClassOf NCIT_C1909 @default.
- NCIT_C78838 subClassOf NCIT_C20401 @default.
- NCIT_C78838 subClassOf NCIT_C274 @default.
- NCIT_C78838 subClassOf NCIT_C307 @default.
- NCIT_C78838 subClassOf NCIT_C308 @default.
- NCIT_C78838 subClassOf NCIT_C78838 @default.