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- NCIT_C78839 IAO_0000115 "An immunoconjugate consisting of an anti-integrin monoclonal antibody covalently attached to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic activity. Integrin-targeted immunoconjugate IMGN388 binds to tumor cell surface integrins; upon internalization, the DM4 moiety is released from the immunoconjugate, binding to tubulin and disrupting microtubule assembly/disassembly dynamics, which may result in inhibition of cell division and cell growth of integrin-expressing tumor cells. Integrins, a class of transmembrane cell surface receptors, link the extracellular matrix (ECM) to intracellular signaling pathways that control cell proliferation and differentiation." @default.
- NCIT_C78839 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78839 NCIT_NHC0 "C78839" @default.
- NCIT_C78839 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78839 NCIT_P108 "Anti-Integrin Monoclonal Antibody-DM4 Immunoconjugate IMGN388" @default.
- NCIT_C78839 NCIT_P208 "CL387679" @default.
- NCIT_C78839 NCIT_P322 "GDC" @default.
- NCIT_C78839 NCIT_P329 "609890" @default.
- NCIT_C78839 NCIT_P330 "609890" @default.
- NCIT_C78839 NCIT_P366 "Anti-Integrin_Immunotoxin_IMGN388" @default.
- NCIT_C78839 NCIT_P375 "Anti-Integrin Monoclonal Antibody-DM4 Immunoconjugate IMGN388" @default.
- NCIT_C78839 NCIT_P399 "609890" @default.
- NCIT_C78839 normalizedInformationContent "100" @default.
- NCIT_C78839 referenceCount "1" @default.
- NCIT_C78839 hasExactSynonym "Anti-Integrin Monoclonal Antibody-DM4 Immunoconjugate IMGN388" @default.
- NCIT_C78839 hasExactSynonym "IMGN388" @default.
- NCIT_C78839 inSubset NCIT_C128784 @default.
- NCIT_C78839 inSubset NCIT_C157711 @default.
- NCIT_C78839 inSubset NCIT_C157712 @default.
- NCIT_C78839 inSubset NCIT_C176424 @default.
- NCIT_C78839 inSubset NCIT_C177537 @default.
- NCIT_C78839 type Class @default.
- NCIT_C78839 isDefinedBy ncit.owl @default.
- NCIT_C78839 label "Anti-Integrin Monoclonal Antibody-DM4 Immunoconjugate IMGN388" @default.
- NCIT_C78839 subClassOf NCIT_C129821 @default.
- NCIT_C78839 subClassOf NCIT_C129823 @default.
- NCIT_C78839 subClassOf NCIT_C1512 @default.
- NCIT_C78839 subClassOf NCIT_C1908 @default.
- NCIT_C78839 subClassOf NCIT_C1909 @default.
- NCIT_C78839 subClassOf NCIT_C274 @default.
- NCIT_C78839 subClassOf NCIT_C307 @default.
- NCIT_C78839 subClassOf NCIT_C308 @default.
- NCIT_C78839 subClassOf NCIT_C575 @default.
- NCIT_C78839 subClassOf NCIT_C78839 @default.