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- NCIT_C78840 IAO_0000115 "An immunoconjugate consisting of a monoclonal antibody directed against syndecan-1 (CD138) covalently attached to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic activity. Upon administration, indatuximab ravtansine binds to syndecan-1-expressing tumor cells; upon internalization the DM4 moiety is released, binding to tubulin and disrupting microtubule assembly/disassembly dynamics, which may result in the inhibition of cell division and cell growth of syndecan-1-expressing tumor cells. Syndecan-1, a type 1 transmembrane proteoglycan and tumor-associated antigen (TAA), is overexpressed in a variety of cancer cells and plays a key role in the regulation of cell growth, differentiation, and adhesion." @default.
- NCIT_C78840 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78840 NCIT_A7 NCIT_C96914 @default.
- NCIT_C78840 NCIT_NHC0 "C78840" @default.
- NCIT_C78840 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78840 NCIT_P107 "Indatuximab Ravtansine" @default.
- NCIT_C78840 NCIT_P108 "Indatuximab Ravtansine" @default.
- NCIT_C78840 NCIT_P208 "CL387726" @default.
- NCIT_C78840 NCIT_P210 "1238517-16-2" @default.
- NCIT_C78840 NCIT_P319 "XGL4M23834" @default.
- NCIT_C78840 NCIT_P322 "CTRP" @default.
- NCIT_C78840 NCIT_P322 "FDA" @default.
- NCIT_C78840 NCIT_P322 "GDC" @default.
- NCIT_C78840 NCIT_P329 "609930" @default.
- NCIT_C78840 NCIT_P330 "609930" @default.
- NCIT_C78840 NCIT_P366 "Maytansinoid-Conjugated_Anti-Myeloma_Monoclonal_Antibody_BT062" @default.
- NCIT_C78840 NCIT_P375 "Anti-Myeloma Monoclonal Antibody-DM4 Immunoconjugate BT-062" @default.
- NCIT_C78840 NCIT_P375 "Indatuximab Ravtansine" @default.
- NCIT_C78840 NCIT_P399 "609930" @default.
- NCIT_C78840 normalizedInformationContent "100" @default.
- NCIT_C78840 referenceCount "1" @default.
- NCIT_C78840 hasExactSynonym "Anti-Myeloma Monoclonal Antibody-DM4 Immunoconjugate BT-062" @default.
- NCIT_C78840 hasExactSynonym "BT-062" @default.
- NCIT_C78840 hasExactSynonym "BT062" @default.
- NCIT_C78840 hasExactSynonym "INDATUXIMAB RAVTANSINE" @default.
- NCIT_C78840 hasExactSynonym "Indatuximab Ravtansine" @default.
- NCIT_C78840 hasExactSynonym "Maytansinoid-Conjugated Anti-Myeloma Monoclonal Antibody BT062" @default.
- NCIT_C78840 inSubset NCIT_C116977 @default.
- NCIT_C78840 inSubset NCIT_C116978 @default.
- NCIT_C78840 inSubset NCIT_C128784 @default.
- NCIT_C78840 inSubset NCIT_C157711 @default.
- NCIT_C78840 inSubset NCIT_C157712 @default.
- NCIT_C78840 inSubset NCIT_C176424 @default.
- NCIT_C78840 inSubset NCIT_C177537 @default.
- NCIT_C78840 inSubset NCIT_C63923 @default.
- NCIT_C78840 type Class @default.
- NCIT_C78840 isDefinedBy ncit.owl @default.
- NCIT_C78840 label "Indatuximab Ravtansine" @default.
- NCIT_C78840 subClassOf NCIT_C129821 @default.
- NCIT_C78840 subClassOf NCIT_C129823 @default.
- NCIT_C78840 subClassOf NCIT_C1512 @default.
- NCIT_C78840 subClassOf NCIT_C1908 @default.
- NCIT_C78840 subClassOf NCIT_C1909 @default.
- NCIT_C78840 subClassOf NCIT_C274 @default.
- NCIT_C78840 subClassOf NCIT_C307 @default.
- NCIT_C78840 subClassOf NCIT_C308 @default.
- NCIT_C78840 subClassOf NCIT_C78840 @default.