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- NCIT_C78843 IAO_0000115 "An orally bioavailable formulation of the ansamycin derivative 17-amino-17-demethoxygeldanamycin (17-AG) with potential antineoplastic activity. Oral Hsp90 inhibitor IPI-493 binds to and inhibits Hsp90, which may result the in growth inhibition in sensitive tumor cell populations. Hsp90, a 90 kDa molecular chaperone, may be highly expressed in tumor cells, playing a key role in the conformational maturation, stability and function of other substrate or "client" proteins within the cell; many of these client proteins are involved in signal transduction, cell cycle regulation and apoptosis, and may include kinases, transcription factors and hormone receptors." @default.
- NCIT_C78843 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78843 NCIT_A7 NCIT_C17766 @default.
- NCIT_C78843 NCIT_NHC0 "C78843" @default.
- NCIT_C78843 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78843 NCIT_P107 "Oral Hsp90 Inhibitor IPI-493" @default.
- NCIT_C78843 NCIT_P108 "Oral Hsp90 Inhibitor IPI-493" @default.
- NCIT_C78843 NCIT_P175 "255109" @default.
- NCIT_C78843 NCIT_P207 "C2703137" @default.
- NCIT_C78843 NCIT_P210 "64202-81-9" @default.
- NCIT_C78843 NCIT_P319 "SLQ1AJG3VB" @default.
- NCIT_C78843 NCIT_P322 "CTRP" @default.
- NCIT_C78843 NCIT_P322 "FDA" @default.
- NCIT_C78843 NCIT_P322 "GDC" @default.
- NCIT_C78843 NCIT_P329 "610131" @default.
- NCIT_C78843 NCIT_P330 "610131" @default.
- NCIT_C78843 NCIT_P366 "Hsp90_Inhibitor_IPI-493" @default.
- NCIT_C78843 NCIT_P375 "Oral Hsp90 Inhibitor IPI-493" @default.
- NCIT_C78843 NCIT_P399 "610131" @default.
- NCIT_C78843 NCIT_R125 NCIT_C17828 @default.
- NCIT_C78843 NCIT_R125 NCIT_C20150 @default.
- NCIT_C78843 NCIT_R125 NCIT_C20480 @default.
- NCIT_C78843 NCIT_R125 NCIT_C40715 @default.
- NCIT_C78843 NCIT_R125 NCIT_C41515 @default.
- NCIT_C78843 NCIT_R125 NCIT_C51037 @default.
- NCIT_C78843 normalizedInformationContent "100" @default.
- NCIT_C78843 referenceCount "1" @default.
- NCIT_C78843 hasExactSynonym "17-Aminodemethoxygeldanamycin" @default.
- NCIT_C78843 hasExactSynonym "17-Aminogeldanamycin" @default.
- NCIT_C78843 hasExactSynonym "Heat Shock Protein 90 Inhibitor IPI-493" @default.
- NCIT_C78843 hasExactSynonym "IPI-493" @default.
- NCIT_C78843 hasExactSynonym "Oral Hsp90 Inhibitor IPI-493" @default.
- NCIT_C78843 inSubset NCIT_C116977 @default.
- NCIT_C78843 inSubset NCIT_C116978 @default.
- NCIT_C78843 inSubset NCIT_C128784 @default.
- NCIT_C78843 inSubset NCIT_C157711 @default.
- NCIT_C78843 inSubset NCIT_C157712 @default.
- NCIT_C78843 inSubset NCIT_C176424 @default.
- NCIT_C78843 inSubset NCIT_C177537 @default.
- NCIT_C78843 inSubset NCIT_C63923 @default.
- NCIT_C78843 type Class @default.
- NCIT_C78843 isDefinedBy ncit.owl @default.
- NCIT_C78843 label "Oral Hsp90 Inhibitor IPI-493" @default.
- NCIT_C78843 subClassOf NCIT_C129824 @default.
- NCIT_C78843 subClassOf NCIT_C156880 @default.
- NCIT_C78843 subClassOf NCIT_C1908 @default.
- NCIT_C78843 subClassOf NCIT_C1909 @default.
- NCIT_C78843 subClassOf NCIT_C2189 @default.
- NCIT_C78843 subClassOf NCIT_C274 @default.
- NCIT_C78843 subClassOf NCIT_C74526 @default.
- NCIT_C78843 subClassOf NCIT_C78843 @default.