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- NCIT_C78846 IAO_0000115 "A small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to other molecules involved in cell cycle regulation and immune responses." @default.
- NCIT_C78846 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78846 NCIT_A7 NCIT_C17766 @default.
- NCIT_C78846 NCIT_NHC0 "C78846" @default.
- NCIT_C78846 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78846 NCIT_P107 "Hsp90 Inhibitor BIIB028" @default.
- NCIT_C78846 NCIT_P108 "Hsp90 Inhibitor BIIB028" @default.
- NCIT_C78846 NCIT_P208 "CL387614" @default.
- NCIT_C78846 NCIT_P210 "911398-13-5" @default.
- NCIT_C78846 NCIT_P319 "KD4GWWK597" @default.
- NCIT_C78846 NCIT_P322 "CTRP" @default.
- NCIT_C78846 NCIT_P322 "FDA" @default.
- NCIT_C78846 NCIT_P322 "GDC" @default.
- NCIT_C78846 NCIT_P329 "612037" @default.
- NCIT_C78846 NCIT_P330 "612037" @default.
- NCIT_C78846 NCIT_P366 "Hsp90_Inhibitor_BIIB02" @default.
- NCIT_C78846 NCIT_P375 "Hsp90 Inhibitor BIIB028" @default.
- NCIT_C78846 NCIT_P399 "612037" @default.
- NCIT_C78846 NCIT_R125 NCIT_C17828 @default.
- NCIT_C78846 NCIT_R125 NCIT_C20150 @default.
- NCIT_C78846 NCIT_R125 NCIT_C20480 @default.
- NCIT_C78846 NCIT_R125 NCIT_C40715 @default.
- NCIT_C78846 NCIT_R125 NCIT_C41515 @default.
- NCIT_C78846 NCIT_R125 NCIT_C51037 @default.
- NCIT_C78846 normalizedInformationContent "100" @default.
- NCIT_C78846 referenceCount "1" @default.
- NCIT_C78846 hasExactSynonym "BIIB-028" @default.
- NCIT_C78846 hasExactSynonym "BIIB028" @default.
- NCIT_C78846 hasExactSynonym "Hsp90 Inhibitor BIIB028" @default.
- NCIT_C78846 inSubset NCIT_C116977 @default.
- NCIT_C78846 inSubset NCIT_C116978 @default.
- NCIT_C78846 inSubset NCIT_C128784 @default.
- NCIT_C78846 inSubset NCIT_C157711 @default.
- NCIT_C78846 inSubset NCIT_C157712 @default.
- NCIT_C78846 inSubset NCIT_C176424 @default.
- NCIT_C78846 inSubset NCIT_C177537 @default.
- NCIT_C78846 inSubset NCIT_C63923 @default.
- NCIT_C78846 type Class @default.
- NCIT_C78846 isDefinedBy ncit.owl @default.
- NCIT_C78846 label "Hsp90 Inhibitor BIIB028" @default.
- NCIT_C78846 subClassOf NCIT_C129824 @default.
- NCIT_C78846 subClassOf NCIT_C156880 @default.
- NCIT_C78846 subClassOf NCIT_C1908 @default.
- NCIT_C78846 subClassOf NCIT_C1909 @default.
- NCIT_C78846 subClassOf NCIT_C2189 @default.
- NCIT_C78846 subClassOf NCIT_C274 @default.
- NCIT_C78846 subClassOf NCIT_C74526 @default.
- NCIT_C78846 subClassOf NCIT_C78846 @default.