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- NCIT_C78848 IAO_0000115 "A small-molecule wortmannin analogue inhibitor of the alpha, gamma, and delta isoforms of phosphoinositide 3-kinase (PI3K) with potential antineoplastic activity. Sonolisib inhibits the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents." @default.
- NCIT_C78848 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78848 NCIT_A7 NCIT_C113631 @default.
- NCIT_C78848 NCIT_A7 NCIT_C30168 @default.
- NCIT_C78848 NCIT_A7 NCIT_C30171 @default.
- NCIT_C78848 NCIT_NHC0 "C78848" @default.
- NCIT_C78848 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78848 NCIT_P107 "Sonolisib" @default.
- NCIT_C78848 NCIT_P108 "Sonolisib" @default.
- NCIT_C78848 NCIT_P207 "C1566038" @default.
- NCIT_C78848 NCIT_P210 "502632-66-8" @default.
- NCIT_C78848 NCIT_P319 "987796874T" @default.
- NCIT_C78848 NCIT_P322 "CTRP" @default.
- NCIT_C78848 NCIT_P322 "FDA" @default.
- NCIT_C78848 NCIT_P322 "GDC" @default.
- NCIT_C78848 NCIT_P329 "612038" @default.
- NCIT_C78848 NCIT_P330 "612038" @default.
- NCIT_C78848 NCIT_P366 "PI3K_Inhibitor_PX-866" @default.
- NCIT_C78848 NCIT_P375 "Sonolisib" @default.
- NCIT_C78848 NCIT_P399 "612038" @default.
- NCIT_C78848 normalizedInformationContent "100" @default.
- NCIT_C78848 referenceCount "1" @default.
- NCIT_C78848 hasExactSynonym "(4E)-4-(((Bis(prop-2-en-1-yl)amino)methylidene)-6-hydroxy-1alpha-(methoxymethyl)-3,7,17-trioxo-2-oxaandrosta-5,8-dien-11alpha-yl Acetate" @default.
- NCIT_C78848 hasExactSynonym "PX 866" @default.
- NCIT_C78848 hasExactSynonym "PX-866" @default.
- NCIT_C78848 hasExactSynonym "PX866" @default.
- NCIT_C78848 hasExactSynonym "SONOLISIB" @default.
- NCIT_C78848 hasExactSynonym "Sonolisib" @default.
- NCIT_C78848 hasExactSynonym "acetic acid (1S,4E,10R,11R,13S,14R)-4-diallylaminomethylene-6-hydroxy-1-methoxymethyl-10,13-dimethyl-3,7,17-trioxo-1,3,4,7,10,11,12,13,14,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester" @default.
- NCIT_C78848 hasExactSynonym "acetic acid 4-diallylaminomethylene-6-hydroxy-1-alpha 12-methoxymethyl-10beta,13beta-dimethyl-3,7,17-trioxo-1,3,4,7,10,11beta,12,13,14alpha,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester" @default.
- NCIT_C78848 inSubset NCIT_C116977 @default.
- NCIT_C78848 inSubset NCIT_C116978 @default.
- NCIT_C78848 inSubset NCIT_C128784 @default.
- NCIT_C78848 inSubset NCIT_C157711 @default.
- NCIT_C78848 inSubset NCIT_C157712 @default.
- NCIT_C78848 inSubset NCIT_C176424 @default.
- NCIT_C78848 inSubset NCIT_C177537 @default.
- NCIT_C78848 inSubset NCIT_C63923 @default.
- NCIT_C78848 type Class @default.
- NCIT_C78848 isDefinedBy ncit.owl @default.
- NCIT_C78848 label "Sonolisib" @default.
- NCIT_C78848 subClassOf NCIT_C129824 @default.
- NCIT_C78848 subClassOf NCIT_C129825 @default.
- NCIT_C78848 subClassOf NCIT_C1404 @default.
- NCIT_C78848 subClassOf NCIT_C163758 @default.
- NCIT_C78848 subClassOf NCIT_C1742 @default.
- NCIT_C78848 subClassOf NCIT_C1908 @default.
- NCIT_C78848 subClassOf NCIT_C1909 @default.
- NCIT_C78848 subClassOf NCIT_C2152 @default.
- NCIT_C78848 subClassOf NCIT_C2189 @default.
- NCIT_C78848 subClassOf NCIT_C274 @default.
- NCIT_C78848 subClassOf NCIT_C471 @default.
- NCIT_C78848 subClassOf NCIT_C78848 @default.