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- NCIT_C78850 IAO_0000115 "A multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC." @default.
- NCIT_C78850 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78850 NCIT_A7 NCIT_C16682 @default.
- NCIT_C78850 NCIT_A7 NCIT_C17068 @default.
- NCIT_C78850 NCIT_A7 NCIT_C17319 @default.
- NCIT_C78850 NCIT_NHC0 "C78850" @default.
- NCIT_C78850 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78850 NCIT_P107 "HDAC/EGFR/HER2 Inhibitor CUDC-101" @default.
- NCIT_C78850 NCIT_P108 "HDAC/EGFR/HER2 Inhibitor CUDC-101" @default.
- NCIT_C78850 NCIT_P207 "C2703140" @default.
- NCIT_C78850 NCIT_P210 "1012054-59-9" @default.
- NCIT_C78850 NCIT_P319 "1A7Y9MP123" @default.
- NCIT_C78850 NCIT_P322 "CTRP" @default.
- NCIT_C78850 NCIT_P322 "FDA" @default.
- NCIT_C78850 NCIT_P322 "GDC" @default.
- NCIT_C78850 NCIT_P329 "612729" @default.
- NCIT_C78850 NCIT_P330 "612729" @default.
- NCIT_C78850 NCIT_P366 "HDAC_EGFR_HER2_Inhibitor_CUDC-101" @default.
- NCIT_C78850 NCIT_P375 "HDAC/EGFR/HER2 Inhibitor CUDC-101" @default.
- NCIT_C78850 NCIT_P399 "612729" @default.
- NCIT_C78850 normalizedInformationContent "100" @default.
- NCIT_C78850 referenceCount "1" @default.
- NCIT_C78850 hasExactSynonym "CUDC-101" @default.
- NCIT_C78850 hasExactSynonym "HDAC/EGFR/HER2 Inhibitor CUDC-101" @default.
- NCIT_C78850 inSubset NCIT_C116977 @default.
- NCIT_C78850 inSubset NCIT_C116978 @default.
- NCIT_C78850 inSubset NCIT_C128784 @default.
- NCIT_C78850 inSubset NCIT_C157711 @default.
- NCIT_C78850 inSubset NCIT_C157712 @default.
- NCIT_C78850 inSubset NCIT_C176424 @default.
- NCIT_C78850 inSubset NCIT_C177537 @default.
- NCIT_C78850 inSubset NCIT_C63923 @default.
- NCIT_C78850 type Class @default.
- NCIT_C78850 isDefinedBy ncit.owl @default.
- NCIT_C78850 label "HDAC/EGFR/HER2 Inhibitor CUDC-101" @default.
- NCIT_C78850 subClassOf NCIT_C129824 @default.
- NCIT_C78850 subClassOf NCIT_C129825 @default.
- NCIT_C78850 subClassOf NCIT_C1404 @default.
- NCIT_C78850 subClassOf NCIT_C159156 @default.
- NCIT_C78850 subClassOf NCIT_C163758 @default.
- NCIT_C78850 subClassOf NCIT_C163760 @default.
- NCIT_C78850 subClassOf NCIT_C163952 @default.
- NCIT_C78850 subClassOf NCIT_C1908 @default.
- NCIT_C78850 subClassOf NCIT_C1909 @default.
- NCIT_C78850 subClassOf NCIT_C1946 @default.
- NCIT_C78850 subClassOf NCIT_C1967 @default.
- NCIT_C78850 subClassOf NCIT_C2167 @default.
- NCIT_C78850 subClassOf NCIT_C2189 @default.
- NCIT_C78850 subClassOf NCIT_C274 @default.
- NCIT_C78850 subClassOf NCIT_C471 @default.
- NCIT_C78850 subClassOf NCIT_C78850 @default.