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- NCIT_C78852 IAO_0000115 "A fully human monoclonal antibody directed against programmed cell death-1 ligand 1 (PD-L1) with immune checkpoint inhibitory and potential antineoplastic activities. Anti-PD-L1 monoclonal antibody MDX-1105 binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1), which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in immune evasion. PD-1, a transmembrane protein expressed on activated T-cells, is a negative regulator of the immune system that limits the expansion and survival of CD8+ T cells." @default.
- NCIT_C78852 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78852 NCIT_A7 NCIT_C96024 @default.
- NCIT_C78852 NCIT_NHC0 "C78852" @default.
- NCIT_C78852 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78852 NCIT_P107 "Anti-PD-L1 Monoclonal Antibody MDX-1105" @default.
- NCIT_C78852 NCIT_P108 "Anti-PD-L1 Monoclonal Antibody MDX-1105" @default.
- NCIT_C78852 NCIT_P208 "CL387680" @default.
- NCIT_C78852 NCIT_P319 "TLZ6R6973Z" @default.
- NCIT_C78852 NCIT_P322 "CTRP" @default.
- NCIT_C78852 NCIT_P322 "FDA" @default.
- NCIT_C78852 NCIT_P322 "GDC" @default.
- NCIT_C78852 NCIT_P329 "612730" @default.
- NCIT_C78852 NCIT_P330 "612730" @default.
- NCIT_C78852 NCIT_P366 "Anti-PD-L1_Monoclonal_Antibody_MDX-1105" @default.
- NCIT_C78852 NCIT_P375 "Anti-PD-L1 Monoclonal Antibody MDX-1105" @default.
- NCIT_C78852 NCIT_P399 "612730" @default.
- NCIT_C78852 NCIT_R124 NCIT_C17710 @default.
- NCIT_C78852 NCIT_R124 NCIT_C17828 @default.
- NCIT_C78852 NCIT_R124 NCIT_C18219 @default.
- NCIT_C78852 NCIT_R124 NCIT_C19986 @default.
- NCIT_C78852 NCIT_R124 NCIT_C40474 @default.
- NCIT_C78852 normalizedInformationContent "100" @default.
- NCIT_C78852 referenceCount "1" @default.
- NCIT_C78852 hasExactSynonym "Anti-PD-L1 Monoclonal Antibody MDX-1105" @default.
- NCIT_C78852 hasExactSynonym "BMS 936559" @default.
- NCIT_C78852 hasExactSynonym "BMS-936559" @default.
- NCIT_C78852 hasExactSynonym "MDX-1105" @default.
- NCIT_C78852 inSubset NCIT_C116977 @default.
- NCIT_C78852 inSubset NCIT_C116978 @default.
- NCIT_C78852 inSubset NCIT_C128784 @default.
- NCIT_C78852 inSubset NCIT_C157711 @default.
- NCIT_C78852 inSubset NCIT_C157712 @default.
- NCIT_C78852 inSubset NCIT_C176424 @default.
- NCIT_C78852 inSubset NCIT_C177537 @default.
- NCIT_C78852 inSubset NCIT_C63923 @default.
- NCIT_C78852 type Class @default.
- NCIT_C78852 isDefinedBy ncit.owl @default.
- NCIT_C78852 label "Anti-PD-L1 Monoclonal Antibody MDX-1105" @default.
- NCIT_C78852 subClassOf NCIT_C128057 @default.
- NCIT_C78852 subClassOf NCIT_C129821 @default.
- NCIT_C78852 subClassOf NCIT_C129822 @default.
- NCIT_C78852 subClassOf NCIT_C141144 @default.
- NCIT_C78852 subClassOf NCIT_C143250 @default.
- NCIT_C78852 subClassOf NCIT_C156893 @default.
- NCIT_C78852 subClassOf NCIT_C163758 @default.
- NCIT_C78852 subClassOf NCIT_C1908 @default.
- NCIT_C78852 subClassOf NCIT_C1909 @default.
- NCIT_C78852 subClassOf NCIT_C191689 @default.
- NCIT_C78852 subClassOf NCIT_C20401 @default.
- NCIT_C78852 subClassOf NCIT_C274 @default.
- NCIT_C78852 subClassOf NCIT_C307 @default.
- NCIT_C78852 subClassOf NCIT_C308 @default.
- NCIT_C78852 subClassOf NCIT_C78852 @default.