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- NCIT_C78856 IAO_0000115 "An inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD8055 inhibits the serine/threonine kinase activity of mTOR, resulting in decreased expression of mRNAs necessary for cell cycle progression, which may induce cell cycle arrest and tumor cell apoptosis. mTOR phosphorylates transcription factors, such as S6K1 and 4E-BP1, which stimulate protein synthesis and regulate cell growth, proliferation, motility, and survival." @default.
- NCIT_C78856 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78856 NCIT_NHC0 "C78856" @default.
- NCIT_C78856 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78856 NCIT_P107 "mTOR Kinase Inhibitor AZD8055" @default.
- NCIT_C78856 NCIT_P108 "mTOR Kinase Inhibitor AZD8055" @default.
- NCIT_C78856 NCIT_P207 "C2703143" @default.
- NCIT_C78856 NCIT_P210 "1009298-09-2" @default.
- NCIT_C78856 NCIT_P319 "970JJ37FPW" @default.
- NCIT_C78856 NCIT_P322 "CTRP" @default.
- NCIT_C78856 NCIT_P322 "FDA" @default.
- NCIT_C78856 NCIT_P322 "GDC" @default.
- NCIT_C78856 NCIT_P329 "612860" @default.
- NCIT_C78856 NCIT_P330 "612860" @default.
- NCIT_C78856 NCIT_P366 "mTOR_Kinase_Inhibitor_AZD8055" @default.
- NCIT_C78856 NCIT_P375 "mTOR Kinase Inhibitor AZD8055" @default.
- NCIT_C78856 NCIT_P399 "612860" @default.
- NCIT_C78856 normalizedInformationContent "100" @default.
- NCIT_C78856 referenceCount "1" @default.
- NCIT_C78856 hasExactSynonym "AZD-8055" @default.
- NCIT_C78856 hasExactSynonym "AZD8055" @default.
- NCIT_C78856 hasExactSynonym "mTOR Kinase Inhibitor AZD8055" @default.
- NCIT_C78856 inSubset NCIT_C116977 @default.
- NCIT_C78856 inSubset NCIT_C116978 @default.
- NCIT_C78856 inSubset NCIT_C128784 @default.
- NCIT_C78856 inSubset NCIT_C157711 @default.
- NCIT_C78856 inSubset NCIT_C157712 @default.
- NCIT_C78856 inSubset NCIT_C176424 @default.
- NCIT_C78856 inSubset NCIT_C177537 @default.
- NCIT_C78856 inSubset NCIT_C63923 @default.
- NCIT_C78856 type Class @default.
- NCIT_C78856 isDefinedBy ncit.owl @default.
- NCIT_C78856 label "mTOR Kinase Inhibitor AZD8055" @default.
- NCIT_C78856 subClassOf NCIT_C129824 @default.
- NCIT_C78856 subClassOf NCIT_C129825 @default.
- NCIT_C78856 subClassOf NCIT_C1404 @default.
- NCIT_C78856 subClassOf NCIT_C163758 @default.
- NCIT_C78856 subClassOf NCIT_C1908 @default.
- NCIT_C78856 subClassOf NCIT_C1909 @default.
- NCIT_C78856 subClassOf NCIT_C2189 @default.
- NCIT_C78856 subClassOf NCIT_C2201 @default.
- NCIT_C78856 subClassOf NCIT_C274 @default.
- NCIT_C78856 subClassOf NCIT_C471 @default.
- NCIT_C78856 subClassOf NCIT_C61074 @default.
- NCIT_C78856 subClassOf NCIT_C78856 @default.