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- NCIT_C78865 IAO_0000115 "An immunotherapeutic consisting of the recombinant fusion protein WT1-A10 combined with the adjuvant ASO1B with potential immunostimulating and antineoplastic activities. Upon administration, WT1-A10/AS01B immunotherapeutic GSK2130579AWT1 may induce a WT1-specific cytotoxic T-lymphocyte (CTL) response against WT1-expressing tumor cells, resulting in cell lysis and the inhibition of cellular proliferation. The tumor-associated antigen WT1 (Wilms tumor protein-1) is overexpressed in most types of leukemia and in a variety of solid cancers. WT1-A10 is a 292 amino acid recombinant fusion protein consisting of a 12-mer truncated tat sequence (leader sequence) and amino acids number 2-281 of the WT1 sequence; ASO1B consists of a combination of the adjuvants monophosporyl lipd A (MPL) and Q21." @default.
- NCIT_C78865 NCIT_A32 NCIT_C1909 @default.
- NCIT_C78865 NCIT_A7 NCIT_C17549 @default.
- NCIT_C78865 NCIT_NHC0 "C78865" @default.
- NCIT_C78865 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C78865 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C78865 NCIT_P107 "WT1-A10/AS01B Immunotherapeutic GSK2130579A" @default.
- NCIT_C78865 NCIT_P108 "WT1-A10/AS01B Immunotherapeutic GSK2130579A" @default.
- NCIT_C78865 NCIT_P208 "CL387745" @default.
- NCIT_C78865 NCIT_P322 "CTRP" @default.
- NCIT_C78865 NCIT_P322 "GDC" @default.
- NCIT_C78865 NCIT_P329 "610132" @default.
- NCIT_C78865 NCIT_P330 "610132" @default.
- NCIT_C78865 NCIT_P366 "WT1_Vaccine_GSK2130579A" @default.
- NCIT_C78865 NCIT_P375 "WT1-A10/AS01B Immunotherapeutic GSK2130579A" @default.
- NCIT_C78865 NCIT_P399 "610132" @default.
- NCIT_C78865 NCIT_R124 NCIT_C17828 @default.
- NCIT_C78865 NCIT_R124 NCIT_C17930 @default.
- NCIT_C78865 NCIT_R124 NCIT_C17937 @default.
- NCIT_C78865 NCIT_R124 NCIT_C18839 @default.
- NCIT_C78865 NCIT_R124 NCIT_C21124 @default.
- NCIT_C78865 NCIT_R124 NCIT_C45548 @default.
- NCIT_C78865 normalizedInformationContent "100" @default.
- NCIT_C78865 referenceCount "1" @default.
- NCIT_C78865 hasExactSynonym "GSK2130579A" @default.
- NCIT_C78865 hasExactSynonym "WT1-A10/AS01B Immunotherapeutic GSK2130579A" @default.
- NCIT_C78865 inSubset NCIT_C116977 @default.
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- NCIT_C78865 inSubset NCIT_C176424 @default.
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- NCIT_C78865 type Class @default.
- NCIT_C78865 isDefinedBy ncit.owl @default.
- NCIT_C78865 label "WT1-A10/AS01B Immunotherapeutic GSK2130579A" @default.
- NCIT_C78865 subClassOf NCIT_C129820 @default.
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- NCIT_C78865 subClassOf NCIT_C1908 @default.
- NCIT_C78865 subClassOf NCIT_C1909 @default.
- NCIT_C78865 subClassOf NCIT_C274 @default.
- NCIT_C78865 subClassOf NCIT_C307 @default.
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- NCIT_C78865 subClassOf NCIT_C78865 @default.
- NCIT_C78865 subClassOf NCIT_C923 @default.