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- NCIT_C792 IAO_0000115 "A polyphenolic flavonoid with potential chemopreventive activity. Quercetin, ubiquitous in plant food sources and a major bioflavonoid in the human diet, may produce antiproliferative effects resulting from the modulation of either EGFR or estrogen-receptor mediated signal transduction pathways. Although the mechanism of action of action is not fully known, the following effects have been described with this agent in vitro: decreased expression of mutant p53 protein and p21-ras oncogene, induction of cell cycle arrest at the G1 phase and inhibition of heat shock protein synthesis. This compound also demonstrates synergy and reversal of the multidrug resistance phenotype, when combined with chemotherapeutic drugs, in vitro. Quercetin also produces anti-inflammatory and anti-allergy effects mediated through the inhibition of the lipoxygenase and cyclooxygenase pathways, thereby preventing the production of pro-inflammatory mediators." @default.
- NCIT_C792 NCIT_NHC0 "C792" @default.
- NCIT_C792 NCIT_P106 "Organic Chemical" @default.
- NCIT_C792 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C792 NCIT_P107 "Quercetin" @default.
- NCIT_C792 NCIT_P108 "Quercetin" @default.
- NCIT_C792 NCIT_P175 "9219" @default.
- NCIT_C792 NCIT_P207 "C0034392" @default.
- NCIT_C792 NCIT_P210 "117-39-5" @default.
- NCIT_C792 NCIT_P319 "9IKM0I5T1E" @default.
- NCIT_C792 NCIT_P322 "CRCH" @default.
- NCIT_C792 NCIT_P322 "CTRP" @default.
- NCIT_C792 NCIT_P322 "FDA" @default.
- NCIT_C792 NCIT_P325 "A kaempferol with a hydroxyl group at C-3'." @default.
- NCIT_C792 NCIT_P329 "43114" @default.
- NCIT_C792 NCIT_P330 "43114" @default.
- NCIT_C792 NCIT_P350 "C15H10O7" @default.
- NCIT_C792 NCIT_P355 "mg" @default.
- NCIT_C792 NCIT_P366 "Quercetin" @default.
- NCIT_C792 NCIT_P368 "CHEBI:16243" @default.
- NCIT_C792 NCIT_P399 "43114" @default.
- NCIT_C792 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C792 referenceCount "3" @default.
- NCIT_C792 hasExactSynonym "2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one" @default.
- NCIT_C792 hasExactSynonym "2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one" @default.
- NCIT_C792 hasExactSynonym "3,3',4',5,7-Pentahydroxyflavone" @default.
- NCIT_C792 hasExactSynonym "C.I. Natural Yellow 10" @default.
- NCIT_C792 hasExactSynonym "QUERCETIN" @default.
- NCIT_C792 hasExactSynonym "Quercetin" @default.
- NCIT_C792 inSubset NCIT_C116977 @default.
- NCIT_C792 inSubset NCIT_C116978 @default.
- NCIT_C792 inSubset NCIT_C173381 @default.
- NCIT_C792 inSubset NCIT_C173383 @default.
- NCIT_C792 inSubset NCIT_C176424 @default.
- NCIT_C792 inSubset NCIT_C63923 @default.
- NCIT_C792 type Class @default.
- NCIT_C792 isDefinedBy ncit.owl @default.
- NCIT_C792 label "Quercetin" @default.
- NCIT_C792 subClassOf NCIT_C1908 @default.
- NCIT_C792 subClassOf NCIT_C1913 @default.
- NCIT_C792 subClassOf NCIT_C1915 @default.
- NCIT_C792 subClassOf NCIT_C1930 @default.
- NCIT_C792 subClassOf NCIT_C1933 @default.
- NCIT_C792 subClassOf NCIT_C1949 @default.
- NCIT_C792 subClassOf NCIT_C28203 @default.
- NCIT_C792 subClassOf NCIT_C54060 @default.
- NCIT_C792 subClassOf NCIT_C552 @default.
- NCIT_C792 subClassOf NCIT_C553 @default.
- NCIT_C792 subClassOf NCIT_C68456 @default.
- NCIT_C792 subClassOf NCIT_C70553 @default.
- NCIT_C792 subClassOf NCIT_C70554 @default.
- NCIT_C792 subClassOf NCIT_C718 @default.
- NCIT_C792 subClassOf NCIT_C792 @default.