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- NCIT_C794 IAO_0000115 "A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)" @default.
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- NCIT_C794 NCIT_NHC0 "C794" @default.
- NCIT_C794 NCIT_P106 "Organic Chemical" @default.
- NCIT_C794 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C794 NCIT_P108 "Quinine" @default.
- NCIT_C794 NCIT_P175 "192949" @default.
- NCIT_C794 NCIT_P207 "C0034417" @default.
- NCIT_C794 NCIT_P210 "130-95-0" @default.
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- NCIT_C794 NCIT_P329 "41253" @default.
- NCIT_C794 NCIT_P330 "41253" @default.
- NCIT_C794 NCIT_P350 "C20H24N2O2" @default.
- NCIT_C794 NCIT_P366 "Quinine" @default.
- NCIT_C794 NCIT_P368 "CHEBI:15854" @default.
- NCIT_C794 NCIT_P375 "Quinine" @default.
- NCIT_C794 NCIT_P399 "41253" @default.
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- NCIT_C794 normalizedInformationContent "88.143637090998837" @default.
- NCIT_C794 referenceCount "6" @default.
- NCIT_C794 hasExactSynonym "(-)-Quinine" @default.
- NCIT_C794 hasExactSynonym "QUIN" @default.
- NCIT_C794 hasExactSynonym "QUININE" @default.
- NCIT_C794 hasExactSynonym "Quinine" @default.
- NCIT_C794 inSubset NCIT_C128784 @default.
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- NCIT_C794 type Class @default.
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- NCIT_C794 label "Quinine" @default.
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- NCIT_C794 subClassOf NCIT_C794 @default.