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- NCIT_C79798 IAO_0000115 "A humanized monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R/CD221) with potential antineoplastic activity. Veligrotug specifically binds to and blocks membrane-bound IGF-1R, preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signal transduction, which may result in the induction of apoptosis and a decrease in cellular proliferation. Activation of IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by various cancer cell types, stimulates cell proliferation, promotes angiogenesis, enables oncogenic transformation, and suppresses apoptosis." @default.
- NCIT_C79798 NCIT_A32 NCIT_C1909 @default.
- NCIT_C79798 NCIT_NHC0 "C79798" @default.
- NCIT_C79798 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C79798 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C79798 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C79798 NCIT_P108 "Veligrotug" @default.
- NCIT_C79798 NCIT_P207 "C2703165" @default.
- NCIT_C79798 NCIT_P210 "1242567-05-0" @default.
- NCIT_C79798 NCIT_P319 "Z9U2SS9ZC8" @default.
- NCIT_C79798 NCIT_P322 "FDA" @default.
- NCIT_C79798 NCIT_P322 "GDC" @default.
- NCIT_C79798 NCIT_P329 "619043" @default.
- NCIT_C79798 NCIT_P330 "619043" @default.
- NCIT_C79798 NCIT_P366 "Anti-IGF-1R_Monoclonal_Antibody_AVE1642" @default.
- NCIT_C79798 NCIT_P375 "Anti-IGF-1R Monoclonal Antibody AVE1642" @default.
- NCIT_C79798 NCIT_P399 "619043" @default.
- NCIT_C79798 NCIT_R124 NCIT_C17710 @default.
- NCIT_C79798 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C79798 NCIT_R124 NCIT_C19986 @default.
- NCIT_C79798 NCIT_R124 NCIT_C40474 @default.
- NCIT_C79798 NCIT_R125 NCIT_C16298 @default.
- NCIT_C79798 NCIT_R125 NCIT_C17709 @default.
- NCIT_C79798 NCIT_R125 NCIT_C17828 @default.
- NCIT_C79798 NCIT_R125 NCIT_C17930 @default.
- NCIT_C79798 NCIT_R125 NCIT_C17937 @default.
- NCIT_C79798 NCIT_R125 NCIT_C18839 @default.
- NCIT_C79798 NCIT_R125 NCIT_C21124 @default.
- NCIT_C79798 normalizedInformationContent "100" @default.
- NCIT_C79798 referenceCount "1" @default.
- NCIT_C79798 hasExactSynonym "AVE-1642" @default.
- NCIT_C79798 hasExactSynonym "AVE1642" @default.
- NCIT_C79798 hasExactSynonym "Anti-IGF-1R Monoclonal Antibody AVE1642" @default.
- NCIT_C79798 hasExactSynonym "VELIGROTUG" @default.
- NCIT_C79798 hasExactSynonym "Veligrotug" @default.
- NCIT_C79798 hasExactSynonym "anti-CD122 monoclonal antibody AVE1642" @default.
- NCIT_C79798 inSubset NCIT_C128784 @default.
- NCIT_C79798 inSubset NCIT_C157711 @default.
- NCIT_C79798 inSubset NCIT_C157712 @default.
- NCIT_C79798 inSubset NCIT_C176424 @default.
- NCIT_C79798 inSubset NCIT_C177537 @default.
- NCIT_C79798 inSubset NCIT_C63923 @default.
- NCIT_C79798 type Class @default.
- NCIT_C79798 isDefinedBy ncit.owl @default.
- NCIT_C79798 label "Veligrotug" @default.
- NCIT_C79798 subClassOf B53e3a3f3a3515d7a29c40bfbdfaffe04 @default.
- NCIT_C79798 subClassOf B74504923113f5e0885b77662e9e48ffa @default.
- NCIT_C79798 subClassOf B96af8569cffecc99afb27c7c16378694 @default.
- NCIT_C79798 subClassOf Bce9f89f3dc4896ee1392336a4a417b2f @default.
- NCIT_C79798 subClassOf NCIT_C129821 @default.
- NCIT_C79798 subClassOf NCIT_C129822 @default.
- NCIT_C79798 subClassOf NCIT_C1742 @default.
- NCIT_C79798 subClassOf NCIT_C182012 @default.
- NCIT_C79798 subClassOf NCIT_C1908 @default.
- NCIT_C79798 subClassOf NCIT_C1909 @default.
- NCIT_C79798 subClassOf NCIT_C20401 @default.
- NCIT_C79798 subClassOf NCIT_C274 @default.
- NCIT_C79798 subClassOf NCIT_C307 @default.
- NCIT_C79798 subClassOf NCIT_C308 @default.
- NCIT_C79798 subClassOf NCIT_C79798 @default.