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- NCIT_C79808 IAO_0000115 "A fully human IgG1 monoclonal antibody directed against human vascular endothelial growth factor receptor 1 (VEGFR-1/FLT-1) with potential antiangiogenesis and antineoplastic activities. Icrucumab specifically binds to and inhibits the activity of VEGFR-1, which may prevent the activation of downstream signaling pathways and so inhibit tumor angiogenesis; the subsequent reduction in tumor nutrient supply may inhibit tumor cell proliferation. Tumor cell overexpression of VEGFR-1 may be associated with tumor angiogenesis and tumor cell proliferation and invasion; VEGFR-1 may modulate VEGFR-2 signaling." @default.
- NCIT_C79808 NCIT_A32 NCIT_C1909 @default.
- NCIT_C79808 NCIT_A7 NCIT_C17975 @default.
- NCIT_C79808 NCIT_NHC0 "C79808" @default.
- NCIT_C79808 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C79808 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C79808 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C79808 NCIT_P107 "Icrucumab" @default.
- NCIT_C79808 NCIT_P108 "Icrucumab" @default.
- NCIT_C79808 NCIT_P207 "C2703168" @default.
- NCIT_C79808 NCIT_P210 "1024603-92-6" @default.
- NCIT_C79808 NCIT_P319 "T7H0B1R64U" @default.
- NCIT_C79808 NCIT_P322 "CTRP" @default.
- NCIT_C79808 NCIT_P322 "FDA" @default.
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- NCIT_C79808 NCIT_P329 "625428" @default.
- NCIT_C79808 NCIT_P330 "625428" @default.
- NCIT_C79808 NCIT_P366 "Anti-VEGFR-1_Monoclonal_Antibody_IMC-18F1" @default.
- NCIT_C79808 NCIT_P375 "Icrucumab" @default.
- NCIT_C79808 NCIT_P399 "625428" @default.
- NCIT_C79808 NCIT_R124 NCIT_C17710 @default.
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- NCIT_C79808 normalizedInformationContent "100" @default.
- NCIT_C79808 referenceCount "1" @default.
- NCIT_C79808 hasExactSynonym "Anti-VEGFR-1 Monoclonal Antibody IMC-18F1" @default.
- NCIT_C79808 hasExactSynonym "Anti-Vascular Endothelial Growth Factor Receptor-1 Monoclonal Antibody IMC-18F1" @default.
- NCIT_C79808 hasExactSynonym "ICRUCUMAB" @default.
- NCIT_C79808 hasExactSynonym "IMC-18F1" @default.
- NCIT_C79808 hasExactSynonym "IMC18F1" @default.
- NCIT_C79808 hasExactSynonym "Icrucumab" @default.
- NCIT_C79808 inSubset NCIT_C116977 @default.
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- NCIT_C79808 inSubset NCIT_C128784 @default.
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- NCIT_C79808 inSubset NCIT_C176424 @default.
- NCIT_C79808 inSubset NCIT_C177537 @default.
- NCIT_C79808 inSubset NCIT_C63923 @default.
- NCIT_C79808 type Class @default.
- NCIT_C79808 isDefinedBy ncit.owl @default.
- NCIT_C79808 label "Icrucumab" @default.
- NCIT_C79808 subClassOf B3aa504a30d46260ace7025746e4bfcdd @default.
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- NCIT_C79808 subClassOf NCIT_C79808 @default.
- NCIT_C79808 subClassOf NCIT_C93170 @default.